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4-(N-(1,8-萘酰亚胺))-N-丁酸

4-(N-(1,8-萘酰亚胺))-N-丁酸用途

Virstatin 抑制菌毛系统合成并阻止 A. baumannii 生物膜的形成。Virstatin 还抑制转录激活剂 ToxT 的二聚化。

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4-(N-(1,8-萘酰亚胺))-N-丁酸名称

[ CAS 号 ]:
88909-96-0

[ 中文名 ]:
4-(N-(1,8-萘酰亚胺))-N-丁酸

[ 英文名 ]:
Virstatin

[英文别名 ]:

Isodibut
1,8-naphthalimide-N-butyric acid
Virstatin
4-(N-(1,8-naphthalimide))-n-butyric acid
(1,8-naphthalimido)butanoic acid
N-(4-butanoic acid)-1,8-naphthalimide

4-(N-(1,8-萘酰亚胺))-N-丁酸生物活性

[ 描述 ]:

Virstatin 抑制菌毛系统合成并阻止 A. baumannii 生物膜的形成。Virstatin 还抑制转录激活剂 ToxT 的二聚化。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[ 靶点 ]

ToxT[1]

[参考文献]

[1]. Nait Chabane Y, et al. Virstatin inhibits biofilm formation and motility of Acinetobacter baumannii. BMC Microbiol. 2014 Mar 12;14:62.

[2]. Shakhnovich EA, et al. Virstatin inhibits dimerization of the transcriptional activator ToxT. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2372-7.

4-(N-(1,8-萘酰亚胺))-N-丁酸物理化学性质

[ 密度 ]:
1.403g/cm3

[ 沸点 ]:
536.5ºC at 760 mmHg

[ 分子式 ]:
C₁₆H₁₃NO₄

[ 分子量 ]:
283.28

[ 闪点 ]:
278.3ºC

[ 精确质量 ]:
283.08400

[ PSA ]:
76.37000

[ LogP ]:
1.81750

[ 折射率 ]:
1.672

[ 储存条件 ]:
-20°C，密闭，干燥

4-(N-(1,8-萘酰亚胺))-N-丁酸MSDS

详细MSDS(安全技术说明书)

4-(N-(1,8-萘酰亚胺))-N-丁酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CF6559500

CHEMICAL NAME :: 1H-Benz(de)isoquinoline-2(3H)-butanoic acid, 1,3-dioxo-

CAS REGISTRY NUMBER :: 88909-96-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H13-N-O4

MOLECULAR WEIGHT :: 283.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4598081

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4598081

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4598081

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4-(N-(1,8-萘酰亚胺))-N-丁酸安全信息

[ 海关编码 ]:
2933990090

4-(N-(1,8-萘酰亚胺))-N-丁酸合成路线

详细合成路线

4-(N-(1,8-萘酰亚胺))-N-丁酸上下游产品

4-(N-(1,8-萘酰亚胺))-N-丁酸上游产品

4-(N-(1,8-萘酰亚胺))-N-丁酸下游产品

4-(N-(1,8-萘酰亚胺))-N-丁酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%