N-[2-(二甲基氨基)乙基]-4-吖啶甲酰胺

N-[2-(二甲基氨基)乙基]-4-吖啶甲酰胺用途

DACA 在体外抑制两种必需的核酶,DNA 拓扑异构酶 I (topo I) 和 DNA拓扑异构酶 II (topo II) 。DACA 稳定人白血病 CCRF-CEM 细胞中的 topo I, topo II α 和 topo II β 可切割复合物。

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N-[2-(二甲基氨基)乙基]-4-吖啶甲酰胺名称

[ CAS 号 ]:
89459-25-6

[ 中文名 ]:
N-[2-(二甲基氨基)乙基]-4-吖啶甲酰胺

[ 英文名 ]:
XR-5000

[英文别名 ]:

Acridine carboxamide
N-(2-(Dimethylamino)ethyl)-4-acridinecarboxamide
N-(2-(Dimehtylamino)ehtyl)acridine-4-carboxamide
Daca
4-Acridinecarboxamide,N-(2-(dimethylamino)ethyl)
N-[2-(Dimethyl-amino)ethyl]acridine-4-carboxamide

N-[2-(二甲基氨基)乙基]-4-吖啶甲酰胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶

[参考文献]

[1]. Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. Biochem Pharmacol. 2000;60(6):817-821.

N-[2-(二甲基氨基)乙基]-4-吖啶甲酰胺物理化学性质

[ 密度 ]:
1.182g/cm3

[ 沸点 ]:
544.1ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₁₉N₃O

[ 分子量 ]:
293.36300

[ 闪点 ]:
282.9ºC

[ 精确质量 ]:
293.15300

[ PSA ]:
48.72000

[ LogP ]:
3.25420

[ 折射率 ]:
1.657

[ 储存条件 ]:
2-8°C

N-[2-(二甲基氨基)乙基]-4-吖啶甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7622610

CHEMICAL NAME :: 4-Acridinecarboxamide, N-(2-(dimethylamino)ethyl)-

CAS REGISTRY NUMBER :: 89459-25-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H19-N3-O

MOLECULAR WEIGHT :: 293.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44597 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 150 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,35,1992