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他唑巴坦钠

他唑巴坦钠用途

Tazobactam sodium 是 β-内酰胺酶抑制剂类抗生素。Ceftolozane 与Tazobactam 联合应用,可提高头孢噻嗪对多种产 ESBL 肠杆菌科和部分类杆菌属的抗菌活性。

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他唑巴坦钠名称

[ CAS 号 ]:
89785-84-2

[ 中文名 ]:
他唑巴坦钠

[ 英文名 ]:
Tazobactam Sodium Salt

[中文别名 ]:

泰唑巴坦钠

[英文别名 ]:

Tazobactam Sodium
MFCD00917472
Tazobactam sodium salt
CL 307,579

他唑巴坦钠生物活性

[ 描述 ]:

Tazobactam sodium 是 β-内酰胺酶抑制剂类抗生素。Ceftolozane 与Tazobactam 联合应用,可提高头孢噻嗪对多种产 ESBL 肠杆菌科和部分类杆菌属的抗菌活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Giacobbe DR, et al. Ceftolozane/tazobactam: place in therapy. Expert Rev Anti Infect Ther. 2018;16(4):307‐320.

他唑巴坦钠物理化学性质

[ 密度 ]:
1.92 g/cm3

[ 沸点 ]:
707.1ºC at 760 mmHg

[ 熔点 ]:
140-147ºC

[ 分子式 ]:
C₁₀H₁₁N₄NaO₅S

[ 分子量 ]:
322.27300

[ 闪点 ]:
381.4ºC

[ 精确质量 ]:
322.03500

[ PSA ]:
133.67000

[ 储存条件 ]:
Store at 0-5°C

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, colorless

他唑巴坦钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI0191500

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1- ylmethyl)-, 4,4-dioxide, sodium salt, (2S-(2-alpha,3-beta,5-alpha))-

CAS REGISTRY NUMBER :: 89785-84-2

LAST UPDATED :: 199409

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H11-N4-O5-S.Na

MOLECULAR WEIGHT :: 322.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,588,1986

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他唑巴坦钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XI0191500

[ 海关编码 ]:
2934999090

他唑巴坦钠合成路线

详细合成路线

他唑巴坦钠上下游产品

他唑巴坦钠上游产品

他唑巴坦钠下游产品

他唑巴坦钠海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

他唑巴坦钠文献

Quantification of piperacillin, tazobactam, cefepime, meropenem, ciprofloxacin and linezolid in serum using an isotope dilution UHPLC-MS/MS method with semi-automated sample preparation.

Clin. Chem. Lab Med. 53(5) , 781-91, (2015)

Recent studies have demonstrated highly variable blood concentrations of piperacillin, tazobactam, cefepime, meropenem, ciprofloxacin and linezolid in critically ill patients with a high incidence of ...

DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.

Nucleic Acids Res. 39 , D1035-41., (2011)

DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, ...

Variable susceptibility to piperacillin/tazobactam amongst Klebsiella spp. with extended-spectrum beta-lactamases.

J. Antimicrob. Chemother. 51 , 605-612, (2003)

MICs of piperacillin/tazobactam are conventionally determined by varying the concentration of piperacillin in the presence of a fixed 4 mg/L tazobactam. When tested in this way, the MIC distribution f...

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