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聚乙二醇单甲醚

聚乙二醇单甲醚用途

m-PEG-OH (MW 2000) 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

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聚乙二醇单甲醚名称

[ CAS 号 ]:
9004-74-4

[ 中文名 ]:
聚乙二醇单甲醚

[ 英文名 ]:
m-PEG-OH (MW 2000)

[中文别名 ]:

[英文别名 ]:

MFCD00084416
Methoxypolyethylene glycols

聚乙二醇单甲醚生物活性

[ 描述 ]:

m-PEG-OH (MW 2000) 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

PEGs

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

聚乙二醇单甲醚物理化学性质

[ 密度 ]:
1.08

[ 沸点 ]:
557.1±45.0 °C at 760 mmHg

[ 熔点 ]:
12 ºC

[ 分子式 ]:
C₂₃H₄₈O₁₂

[ 分子量 ]:
516.620

[ 闪点 ]:
268 ºC

[ 精确质量 ]:
516.314575

[ LogP ]:
-4.38

[ 外观性状 ]:
semisolid | White to pale yellow

[ 蒸汽密度 ]:
>1 (vs air)

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.456

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
H2O: 50 mg/mL at 25 °C, clear, colorless

聚乙二醇单甲醚安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
PE8271000

聚乙二醇单甲醚文献

Universal concept for the implementation of a single cleavable unit at tunable position in functional poly(ethylene glycol)s.

Biomacromolecules 14(2) , 448-59, (2013)

Poly(ethylene glycol) (PEG) with acid-sensitive moieties gained attention particularly for various biomedical applications, such as the covalent attachment of PEG (PEGylation) to protein therapeutics,...

Preliminary assessment of the safety evaluation of novel pH-sensitive hydrogel.

Eur. J. Pharm. Biopharm. 82(2) , 332-9, (2012)

In our previous work, a new kind of pH-sensitive hydrogel based on poly (lactic acid) (PLA), methoxyl poly (ethylene glycol) (MPEG) and itaconic acid (IA) was prepared by heat-initiated free radical p...

PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice.

J. Virol. 87(7) , 3752-9, (2013)

We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized i...

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