吐温 60

吐温 60用途

聚氧乙烯山梨醇单硬脂酸酯是饱和脂肪酸硬脂酸(C18:0)的酯。聚氧乙烯山梨醇单硬脂酸酯可用作赋形剂,如表面活性剂、乳化剂、增溶剂、润湿剂等。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

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吐温 60名称

[ CAS 号 ]:
9005-67-8

[ 中文名 ]:
吐温 60

[ 英文名 ]:
Tween 60

[中文别名 ]:

[英文别名 ]:

MFCD01780110
Polyoxyethylene sorbitan monostearate
Polyethylene glycol sorbitan monostearate
polysorbate 60

吐温 60生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Lind ML, et al. Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80. Eur J Pharm Sci. 2008 Oct 2;35(3):211-8.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

吐温 60物理化学性质

[ 密度 ]:
1.081

[ 沸点 ]:
583.8±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₄H₄₆O_6.(C₂H₄O)n

[ 闪点 ]:
190.4±23.6 °C

[ PSA ]:
133.14000

[ LogP ]:
8.09

[ 蒸汽压 ]:
0.0±3.7 mmHg at 25°C

[ 折射率 ]:
1.499

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
100 g/L

吐温 60安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
WG2934000

[ 海关编码 ]:
34021300

吐温 60制备

1.将1 mol斯盘60投入反应釜中，加热熔化后开搅拌，加入催化剂量的氢氧化钠溶液。抽真空减压脱水，脱水完毕后用氮气置换釜中的空气，升温至140℃开始通入环氧乙烷4 mol进行缩合反应，缩合温度维持在160～180℃。通环氧乙烷到配比量后冷却，出料液打入中和釜，用冰醋酸中和至酸值2左右，然后用双氧水脱色，脱水，出料包装即为成品。

2.在甲醇钠(或乙醇钠)的催化下、130～170℃时，Span-60中通入一定量的环氧乙烷发生加成反应得产品。将330 kg乳化剂S-60加入反应釜中，加热熔化后，开搅拌加入催化剂量的氢氧化钠溶液。抽真空减压脱水，用氮气置换釜中的空气，升温至140℃后开始通环氧乙烷700 kg，控制反应温度在160～180℃。环氧乙烷通至配比量后，将料液打入中和釜，用冰醋酸调pH值至酸值2左右，最后用适量的双氧水脱色，冷却包装即为成品。

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吐温 60文献

Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation.

PLoS ONE 6(6) , e20667, (2011)

The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (...

Encapsulation of functional lipophilic components in surfactant-based colloidal delivery systems: vitamin E, vitamin D, and lemon oil.

Food Chem. 134 , 1106-12, (2012)

The fabrication and stability of surfactant-based colloidal delivery systems (microemulsions and emulsions) suitable for encapsulation of lipophilic active agents (vitamins and flavours) was investiga...

Doxorubicin loaded magneto-niosomes for targeted drug delivery.

Colloids Surf. B Biointerfaces , (2013)

In chemotherapy the magnetic drug targeting to a specific organ or tissue is proposed on the assumption that magnetic fields are harmless to biological systems. In this light we have vehiculated doxor...

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