磷酸二酯酶I 来源于东部菱背响尾蛇毒液

磷酸二酯酶I 来源于东部菱背响尾蛇毒液用途

磷酸二酯酶(PDE)是一种能催化环核苷酸3'环磷酸键水解的酶,常用于生化研究。磷酸二酯酶是第二信使分子cAMP和cGMP介导的信号转导的重要调节因子。根据其对环核苷酸的特异性,它们也可分为不同类型,如PDE1-PDE11,其在各种疾病中也具有一定的潜力[1]。

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磷酸二酯酶I 来源于东部菱背响尾蛇毒液名称

[ CAS 号 ]:
9025-82-5

[ 中文名 ]:
磷酸二脂酶

[ 英文名 ]:
Phosphodiesterase

[中文别名 ]:

[英文别名 ]:

ec 3.1.4.1 type iv
ec 3.1.4.1 type v
ec 3.1.4.1 type vi
ec 3.1.4.1
iub: 3.1.4.1
5'-exonuclease
5'-exonuclease type iv
5'-exonuclease type v

磷酸二酯酶I 来源于东部菱背响尾蛇毒液生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 神经疾病

[参考文献]

[1]. Sébastien Delhaye, et al. Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders. Mol Psychiatry. 2021 Sep;26(9):4570-4582.

磷酸二酯酶I 来源于东部菱背响尾蛇毒液物理化学性质

[ 外观性状 ]:
固体

[ 储存条件 ]:
-20°C

磷酸二酯酶I 来源于东部菱背响尾蛇毒液安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SZ5999500

磷酸二酯酶I 来源于东部菱背响尾蛇毒液文献

Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics.

Calcif. Tissue Int. 93(3) , 222-32, (2013)

During endochondral bone formation, chondrocytes and osteoblasts synthesize and mineralize the extracellular matrix through a process that initiates within matrix vesicles (MVs) and ends with bone min...

Contribution of adenosine-producing ectoenzymes to the mechanisms underlying the mitigation of maternal-fetal conflicts.

J. Biol. Regul. Homeost. Agents 27(2) , 519-29, (2013)

The interactions taking place between mother and embryo have been the focus of detailed studies in recent years, where pregnancy is considered as an in vivo transplant. The immune systems of the mothe...

Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.

J. Biol. Chem. 288(41) , 29494-505, (2013)

Bone marrow contains mesenchymal stem cells (MSCs) that can differentiate along multiple mesenchymal lineages. In this capacity they are thought to be important in the intrinsic turnover and repair of...

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