细胞色素P450还原酶

Cytochrome P450 reductase 是一种 NADPH-细胞色素还原酶。Cytochrome P450 reductase 在促进芳香酶构象最适合底物结合方面发挥作用。

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NONH for all modes of transport

The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling.

Biochem. J. 455(1) , 75-85, (2013)

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance...

The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models.

Toxicol. Appl. Pharmacol. 272(1) , 230-7, (2013)

The kidney is a primary target for numerous toxic compounds. Cytochrome P450 enzymes (P450) are responsible for the metabolic activation of various chemical compounds, and in the kidney are predominan...

Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes--a comparative study.

Biotechnol. J. 7(11) , 1346-58, (2012)

The processes of drug development require efficient strategies to produce the respective drug metabolites, which are often difficult to obtain. Biotransformations employing recombinant microorganisms ...

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