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甲苯胺蓝O

甲苯胺蓝O用途

氧化还原指示剂。生物染色剂。组织化学中用于测定脱氧核糖核酸和核糖核酸。诊断白喉。羊毛、丝的印染。

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甲苯胺蓝O名称

[ CAS 号 ]:
92-31-9

[ 中文名 ]:
3-氨基-7-(二甲基氨基)-2-甲基吩噻嗪-5-翁氯化物

[ 英文名 ]:
Toluidine Blue

[中文别名 ]:

[英文别名 ]:

Toluidine Blue O, pure
EINECS 202-146-2
MFCD00011934
T C666 BN ISJ E1 FZ LN1&1 &&Chloride
Tolonium chloride (C.I. 52040)

甲苯胺蓝O生物活性

[ 描述 ]:

甲苯胺蓝是一种碱性噻嗪异染染料,对酸性组织成分有很高的亲和力。甲苯胺蓝在活体组织的活体染色和一种特殊染色中有着广泛的应用[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Sridharan G, et al. Toluidine blue: A review of its chemistry and clinical utility. J Oral Maxillofac Pathol. 2012;16(2):251-255.

甲苯胺蓝O物理化学性质

[ 分子式 ]:
C₁₅H₁₆ClN₃S

[ 分子量 ]:
305.826

[ 精确质量 ]:
305.075348

[ PSA ]:
70.39000

[ LogP ]:
1.27240

[ 外观性状 ]:
暗绿色粉末

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
水溶性：可溶；极微溶：醇

甲苯胺蓝OMSDS

甲苯胺蓝O毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP5670000

CHEMICAL NAME :: Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride

CAS REGISTRY NUMBER :: 92-31-9

LAST UPDATED :: 199706

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C15-H16-N3-S.Cl

MOLECULAR WEIGHT :: 305.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 43 mg/kg/6D

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28930 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27560 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 13440 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1164 No. of Facilities: 224 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1226 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1164 No. of Facilities: 196 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 7956 (estimated) No. of Female Employees: 5824 (estimated)

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甲苯胺蓝O安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F+

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SP5670000

[ 海关编码 ]:
32041300

甲苯胺蓝O合成路线

甲苯胺蓝O上下游产品

甲苯胺蓝O上游产品

甲苯胺蓝O下游产品

甲苯胺蓝O海关

[ 海关编码 ]: 2934300000

[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

甲苯胺蓝O文献

Ligand polarizability contributes to tau fibril binding affinity.

Bioorg. Med. Chem. 19 , 5147-54, (2011)

Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer's disease. Diverse compounds with high affinity for tau aggrega...

The canine epiphyseal-derived mesenchymal stem cells are comparable to bone marrow derived-mesenchymal stem cells.

J. Vet. Med. Sci. 77(3) , 273-80, (2015)

Mesenchymal stem cells (MSCs) hold great potential in cell therapy and have attracted increasing interests in a wide range of biomedical sciences. However, the scarcity of MSCs and the prolonged isola...

Analysis and testing of biological stains--the Biological Stain Commission Procedures.

Biotech. Histochem. 77(5&6) , 237-275, (2002)

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