碘克沙醇

【用途1】
非离子型X-光照影剂。
【用途2】
X－线造影剂。用于成人的心血管造影、脑血管造影(常规的与i.a. DSA)、外周动脉造影(常规的与i.a. DSA)、腹部血管造影(i.a. DSA)、尿路造影、静脉造影以及CT－增强检查。

[ 描述 ]:

[ 相关类别 ]:

[体内研究]

[参考文献]

[ 密度 ]:
2.3±0.1 g/cm3

[ 沸点 ]:
1250.9±65.0 °C at 760 mmHg

[ 熔点 ]:
262-267ºC (dec.)

[ 分子式 ]:
C₃₅H₄₄I₆N₆O₁₅

[ 分子量 ]:
1550.182

[ 闪点 ]:
710.3±34.3 °C

[ 精确质量 ]:
1549.713257

[ PSA ]:
339.09000

[ LogP ]:
-5.88

[ 外观性状 ]:
灰白色至白色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.752

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

CZ3075000

CHEMICAL NAME :

1,3-Benzenedicarboxamide, 5,5'-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis (N,N'- bis(2,3-dihydroxypropyl)-2,4,6-triiodo-

CAS REGISTRY NUMBER :

92339-11-2

LAST UPDATED :

199806

DATA ITEMS CITED :

4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>42757 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - hemorrhage

REFERENCE :

ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

30512 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :

ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

73228 mg/kg/3W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :

ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

54921 mg/kg/3W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :

ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2924299090

详细合成路线

碘克沙醇上游产品

碘克沙醇下游产品

【方法1】
化合物(Ⅰ)和1，3-二氯-2-丙醇缩合，即得碘克沙醇。

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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CD40 is required for protective immunity against liver stage Plasmodium infection.

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Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells.

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Lon is a nuclear-encoded, mitochondrial protease that assists protein folding, degrades oxidized/damaged proteins, and participates in maintaining mtDNA levels. Here we show that Lon is up-regulated i...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：Iodixanol

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Iodixanol

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公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥447.0/5mg ￥1346.0/25mg ￥3930.0/100mg ￥10890.0/1g

联系人：夏言

产品详情：[Perfemiker]Iodixanol,BR

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥597.9/25g ￥199.9/5g ￥1668.9/100g ￥5836.9/500g

联系人：阿拉丁

产品详情：碘克沙醇

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公司名：中山市迪欣化工有限公司

区域：中山市三角镇

价格：
￥2050.0/25kg

联系人：陈雪萍

产品详情：碘克沙醇

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