1,3-二氯丙醇

1,3-二氯丙醇用途

【用途一】
用于抗病毒药更昔洛韦的合成，用作醋酸纤维、乙基纤维的溶剂，也用于制造环氧树脂、离子交换树脂等
【用途二】
用作醋酸纤维、乙基纤维等的溶剂，也用于有机合成
【用途三】
用作乙酸纤维、乙基纤维的溶剂。也是环氧树脂、离子交换树脂、环氧氯丙烷的中间体。
【用途四】
用作乙酸纤维、乙基纤维的溶剂。也是环氧树脂、离子交换树脂、环氧氯丙烷的中间体

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1,3-二氯丙醇名称

[ CAS 号 ]:
96-23-1

[ 中文名 ]:
1,3-二氯-2-丙醇

[ 英文名 ]:
1,3-Dichloro-2-propanol

[中文别名 ]:

[英文别名 ]:

1,3-dichloro-1,3-dideoxyglycerol
2-Propanol, 1,3-dichloro-
glycerol 1,3-dichlorohydrin
U 25,354
1,3-dichloro-2-hydroxypropane
EINECS 202-491-9
1,3-dichlorohydrin
DCP
gdch
1,3-DCP

1,3-二氯丙醇物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
174.3±0.0 °C at 760 mmHg

[ 熔点 ]:
-4 °C

[ 分子式 ]:
C₃H₆Cl₂O

[ 分子量 ]:
128.985

[ 闪点 ]:
85.6±0.0 °C

[ 精确质量 ]:
127.979568

[ PSA ]:
20.23000

[ LogP ]:
0.66

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
0.4±0.7 mmHg at 25°C

[ 折射率 ]:
1.462

[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放

[ 水溶解性 ]:
soluble. >=10 g/100 mL at 23 ºC

1,3-二氯丙醇MSDS

1,3-二氯丙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB1400000

CHEMICAL NAME :: 2-Propanol, 1,3-dichloro-

CAS REGISTRY NUMBER :: 96-23-1

BEILSTEIN REFERENCE NO. :: 1732063

LAST UPDATED :: 199801

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C3-H6-Cl2-O

MOLECULAR WEIGHT :: 128.99

WISWESSER LINE NOTATION :: G1YQ1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 800 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4550 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 250 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5378 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 200 (estimated) No. of Female Employees: 6 (estimated)

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1,3-二氯丙醇安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312-H350

[ 警示性声明 ]:
P201-P280-P301 + P310-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R21;R25;R45

[ 安全声明 (欧洲) ]:
S53-S45-S36/37-S16

[ 危险品运输编码 ]:
UN 2750 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UB1400000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29055910

1,3-二氯丙醇合成路线

1,3-二氯丙醇上下游产品

1,3-二氯丙醇上游产品

1,3-二氯丙醇下游产品

1,3-二氯丙醇制备

1.由氯丙烯与次氯酸反应而得。

2.由甘油在冰醋酸存在的情况下，与氯化氢反应而得。原料消耗定额：甘油796kg/t、氯化氢781.2kg/t、冰醋酸66.2kg/t。

精制方法：减压蒸馏精制。

3.制法：

于称量过的反应瓶中加入90%的甘油(2)500g（4.9mol），10g醋酸，装一根通气管深入至瓶底，油浴加热，控制油浴的温度100～110℃。通入干燥的氯化氢气体(由氯化铵与硫酸反应制备)。开始时氯化氢气体吸收很快，随着时间的延长，吸收逐渐减慢。当质量增加约440g时，停止通氯化氢气体。冷却后减压抽出氯化氢。慢慢加入固体碳酸钠，中和反应体系中的酸，直至呈弱碱性。可适当加入水以利于同碳酸钠的反应，约加水200mL。分出水层，而后减压蒸馏，收集68℃/1.65kPa以下的馏分(约110g)和68～75/1.65kPa的馏分(约385g)。将第一馏分中的水分出后重新蒸馏，收集68～75/1.65kPa的馏分，得约50g产品。将该馏分的产物重新蒸馏，收集70～73/1.65kPa的馏分，得1,3-二氯-2-丙醇^①(1)350g,收率55%。注：①也可由烯丙基氯与次氯酸反应来制备1,3-二氯-2-丙醇，反应式如下。[1]

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1,3-二氯丙醇海关

[ 海关编码 ]: 2905590090

[ 中文概述 ]:
2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1,3-二氯丙醇文献

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Food Chem. 166 , 301-8, (2014)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indi...

Exploring the enantioselective mechanism of halohydrin dehalogenase from Agrobacterium radiobacter AD1 by iterative saturation mutagenesis.

Appl. Environ. Microbiol. 81(8) , 2919-26, (2015)

Halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC) shows great potential in producing valuable chiral epoxides and β-substituted alcohols. The wild-type (WT) enzyme displays a high R-en...

Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity.

Bioorg. Med. Chem. 16 , 5720-32, (2008)

The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...

更多文献

1,3-二氯丙醇

1,3-二氯丙醇用途

1,3-二氯丙醇名称

1,3-二氯丙醇物理化学性质

1,3-二氯丙醇MSDS

详细MSDS(安全技术说明书)

1,3-二氯丙醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,3-二氯丙醇安全信息

1,3-二氯丙醇合成路线

详细合成路线

1,3-二氯丙醇上下游产品

1,3-二氯丙醇上游产品

1,3-二氯丙醇下游产品

1,3-二氯丙醇制备

1,3-二氯丙醇海关

1,3-二氯丙醇文献

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