N-羟甲基丙烯酰胺

N-羟甲基丙烯酰胺用途

【用途一】
可作交联剂，广泛用于纤维的改性树脂、加工染料、塑料粘合剂、土壤稳定剂等
【用途二】
该品分子中具有与羰基共轭的双键和富有反应性的羟甲基，是用途广泛的交联性单体，用于纤维的改性、树脂加工、粘合剂及纸张、皮革、金属表面的处理剂，还可用于土壤改良剂等。雄小鼠口服LD50为420mg/kg。
【用途三】
有机合成单体可用于制备多种共聚物。

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N-羟甲基丙烯酰胺名称

[ CAS 号 ]:
924-42-5

[ 中文名 ]:
N-(羟甲基)丙烯酰胺

[ 英文名 ]:
N-Methylolacrylamide

[中文别名 ]:

[英文别名 ]:

N-(hydroxymethyl)prop-2-enamide
N-(Hydroxymethyl)acrylamide
N-hydroxymethylacrylamide
EINECS 213-103-2
2-Propenamide, N-(hydroxymethyl)-
N-Methylolacrylamide
MFCD00004597

N-羟甲基丙烯酰胺物理化学性质

[ 密度 ]:
1.074

[ 沸点 ]:
318.1±34.0 °C at 760 mmHg

[ 熔点 ]:
74-75°C

[ 分子式 ]:
C₄H₇NO₂

[ 分子量 ]:
101.104

[ 闪点 ]:
146.2±25.7 °C

[ 精确质量 ]:
101.047676

[ PSA ]:
49.33000

[ LogP ]:
-1.48

[ 外观性状 ]:
一种无色或黄色水状的溶液

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.459

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
<0.1 g/100 mL at 20.5 ºC

N-羟甲基丙烯酰胺MSDS

N-羟甲基丙烯酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AS3600000

CHEMICAL NAME :: Acrylamide, N-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 924-42-5

BEILSTEIN REFERENCE NO. :: 0506646

LAST UPDATED :: 199712

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C4-H7-N-O2

MOLECULAR WEIGHT :: 101.12

WISWESSER LINE NOTATION :: Q1MV1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 474 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 563 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 16 gm/kg

TOXIC EFFECTS :: Behavioral - tremor

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8736 mg/kg/27W-C

TOXIC EFFECTS :: Behavioral - muscle weakness

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 mg/kg/16D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3250 mg/kg/13W-I

TOXIC EFFECTS :: Behavioral - ataxia Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4688 mg/kg/8W-I

TOXIC EFFECTS :: Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1625 mg/kg/13W-I

TOXIC EFFECTS :: Behavioral - ataxia Liver - changes in liver weight Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 mg/kg/16D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25750 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4608 mg/kg

SEX/DURATION :: male 16 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 730 gm/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 730 gm/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-352,1989 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81901 No. of Facilities: 154 (estimated) No. of Industries: 7 No. of Occupations: 17 No. of Employees: 2938 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81901 No. of Facilities: 117 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 20665 (estimated) No. of Female Employees: 13852 (estimated)

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N-羟甲基丙烯酰胺安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H317-H340-H350-H361-H372

[ 警示性声明 ]:
P201-P280-P301 + P310 + P330-P333 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
2810

[ WGK德国 ]:
3

[ RTECS号 ]:
AS3600000

[ 海关编码 ]:
2924199090

N-羟甲基丙烯酰胺合成路线

N-羟甲基丙烯酰胺上下游产品

N-羟甲基丙烯酰胺上游产品

N-羟甲基丙烯酰胺下游产品

N-羟甲基丙烯酰胺制备

（1）丙烯酰胺与甲醛缩合法在弱碱性条件下，将丙烯酰胺与37%的甲醛水熔液反应而制得。也可由丙烯酰胺与甲醛在脂肪胺催化剂催化下反应制得N-羟甲基丙烯酰胺。工艺流程：向装有回流冷凝器和搅拌器和三口瓶中加入一定量丙烯酰胺和37%甲醛水溶液，置于恒温水浴中，待丙烯酰胺溶解、水浴升至所需温度时，加入一定量的脂肪胺催化剂，反应完后将反应液脱水，干燥、结晶，分离出晶体，干燥，然后测定含量和熔点合格即为产品。最佳工艺条件为甲醛：丙烯酰胺=1：（1.1-1.0）（mol比），反应温度40-50℃，反应时间40-60min，PH值控制在9.6左右。在此条件下，丙烯酰胺的转化率达92.5%。用水作溶剂即安全又经济。结晶后的母液可循环使用，降低生产成本。一次结晶可得到含量为98%-99%的产品，熔点76-78℃，与文献值78.5-79接近。（2）丙烯腈水解法以28%工业丙烯酰胺水溶液（丙烯腈水解液）与甲醛水溶液在苛性钠催化下，以亚硝酸钠为阻聚剂合成而得。工艺流程：将28%工业丙烯酰胺水溶液、37%甲醛水溶液和苛性钠加入装有搅拌器、回流冷凝管的三口瓶中，不搅拌，控制温度在45-50℃。保持45-50min。然后冷却，结晶，过滤得粗产品。用乙酸乙酯对粗产品进行重结晶（70℃下溶解）即得精制品，收率可达72%。本法与甲醇交换法相比，不使用溶剂二氯甲烷，不必进行溶剂回收，安全、无毒；与离子交换法相比，弱碱性离子交换树脂昂贵，用后需再生；与传统苛性钠催化法相比，不需用结晶丙烯酰胺，简化了合成工艺。（3）丙烯酰胺与多聚甲醛缩合由丙烯酰与多聚甲醛缩合制得N-羟甲基丙烯酰胺。以三氯乙烯为溶剂，金属钠二甲苯胶体为催化剂，丙烯酰胺与多聚甲醛在50℃反应1h，收率达93%。

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N-羟甲基丙烯酰胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-羟甲基丙烯酰胺文献

Protein crystallization and biosensor applications of hydrogel-based molecularly imprinted polymers.

Biomacromolecules 13(12) , 3959-65, (2012)

We have characterized the imprinting capability of a family of acrylamide polymer-based molecularly imprinted polymers (MIPs) for bovine hemoglobin (BHb) and trypsin (Tryp) using spectrophotometric an...

Magnetocaloric effect in magnetothermally-responsive nanocarriers for hyperthermia-triggered drug release.

Nanotechnology 23(50) , 505706, (2012)

The magnetocaloric effects and lower critical solution temperature (LCST) were investigated in a magnetothermally-responsive nanocarrier for magnetothermal drug release under alternating magnetic fiel...

Self-driven gel conveyer: effect of interactions between loaded cargo and self-oscillating gel surface.

Macromol. Biosci. 11(12) , 1713-21, (2011)

A "self-oscillating" gel that swells and deswells periodically under constant conditions is developed as a novel biomimetic gel differing from conventional stimuli-responsive polymer gels. By utilizin...

更多文献

N-羟甲基丙烯酰胺

N-羟甲基丙烯酰胺用途

N-羟甲基丙烯酰胺名称

N-羟甲基丙烯酰胺物理化学性质

N-羟甲基丙烯酰胺MSDS

详细MSDS(安全技术说明书)

N-羟甲基丙烯酰胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

N-羟甲基丙烯酰胺安全信息

N-羟甲基丙烯酰胺合成路线

详细合成路线

N-羟甲基丙烯酰胺上下游产品

N-羟甲基丙烯酰胺上游产品

N-羟甲基丙烯酰胺下游产品

N-羟甲基丙烯酰胺制备

N-羟甲基丙烯酰胺海关

N-羟甲基丙烯酰胺文献

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