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6-二甲基氨基嘌呤

6-二甲基氨基嘌呤用途

6-(Dimethylamino)purine 是蛋白激酶和 CDK 的双抑制剂。

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6-二甲基氨基嘌呤名称

[ CAS 号 ]:
938-55-6

[ 中文名 ]:
6-二甲基氨基嘌呤

[ 英文名 ]:
N6,N6-dimethyladenine

[中文别名 ]:

[英文别名 ]:

UNII:649SA4S2CV
7H-Purin-6-amine, N,N-dimethyl-
N,N-dimethyl-7H-purin-6-amine
N(6),N(6)-dimethyladenine
N,N-Dimethyl-1H-purin-6-amine
N,N-Dimethyl-6-aminopurine
EINECS 214-353-5
N6,N6-dimethyl-Adenine
1H-purin-6-amine, N,N-dimethyl-
Adenine, N6,N6-dimethyl-

6-二甲基氨基嘌呤生物活性

[ 描述 ]:

6-(Dimethylamino)purine 是蛋白激酶和 CDK 的双抑制剂。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 细胞周期/DNA损伤 >> CDK

[参考文献]

[1]. Neant I, et al. 6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity. Exp Cell Res. 1988 May;176(1):68-79.

[2]. Meijer L, et al. Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases. Pharmacol Ther. 1999 May-Jun;82(2-3):279-84.

6-二甲基氨基嘌呤物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
427.4±25.0 °C at 760 mmHg

[ 熔点 ]:
259-262 °C(lit.)

[ 分子式 ]:
C₇H₉N₅

[ 分子量 ]:
163.180

[ 闪点 ]:
212.3±23.2 °C

[ 精确质量 ]:
163.085800

[ PSA ]:
57.70000

[ LogP ]:
1.43

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.718

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
methanol: 0.1 g/mL, clear

6-二甲基氨基嘌呤MSDS

6-二甲基氨基嘌呤安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45-S24/25-S22

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
US9230000

[ 包装等级 ]:
II; III

[ 海关编码 ]:
2933990090

6-二甲基氨基嘌呤合成路线

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6-二甲基氨基嘌呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-二甲基氨基嘌呤文献

Placental development during early pregnancy in sheep: effects of embryo origin on vascularization.

Reproduction 147(5) , 639-48, (2014)

Utero-placental growth and vascular development are critical for pregnancy establishment that may be altered by various factors including assisted reproductive technologies (ART), nutrition, or others...

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Proc. Natl. Acad. Sci. U. S. A. 104 , 20523-8, (2007)

Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under inves...

Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.

Science 347(6221) , 1257277, (2015)

The mechanistic basis of eukaryotic circadian oscillators in model systems as diverse as Neurospora, Drosophila, and mammalian cells is thought to be a transcription-and-translation-based negative fee...

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