碘解磷定
碘解磷定用途
碘解磷定名称
[ CAS 号 ]:
94-63-3
[ 中文名 ]:
碘解磷啶
[ 英文名 ]:
Pralidoxime Iodide
[中文别名 ]:
[英文别名 ]:
- 2-Pyridinealdoxime methiodide
- 2-hydroxyiminomethyl-1-methylpyridinium iodide
- protopamiodide
- EINECS 202-349-6
- 1-methyl-2-hydroxyiminomethylpyridinium iodide
- pralidoximemethiodide
- PRALIDOXIMELODIDE
- PYRIDINE-2-CARBOXALDOXIME METHIODIDE
- PRALIDOXIME IODIDE
- MFCD00011982
碘解磷定生物活性
[ 描述 ]:
[ 相关类别 ]:
[体内研究]
[参考文献]
碘解磷定物理化学性质
[ 密度 ]:
1.7439 g/ml
[ 熔点 ]:
220 °C (dec.)(lit.)
[ 分子式 ]:
C7H9IN2O
[ 分子量 ]:
264.064
[ 精确质量 ]:
263.975952
[ PSA ]:
36.47000
[ 外观性状 ]:
淡黄色针状结晶性粉末
[ 储存条件 ]:
2-8°C
碘解磷定MSDS
碘解磷定毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UU4375000
- CHEMICAL NAME :
- Pyridinium, 2-formyl-1-methyl-, iodide, oxime
- CAS REGISTRY NUMBER :
- 94-63-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C7-H9-N2-O.I
- MOLECULAR WEIGHT :
- 264.08
- WISWESSER LINE NOTATION :
- T6KJ A1 B1UNQ &Q &I
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 305 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 13,202,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 178 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,31,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 249 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,31,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 136 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 60,261,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 5,21,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 145 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 132,50,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,5,1964 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 166,1834,1958 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 50,475,1971
碘解磷定安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
UU4375000
碘解磷定合成路线
碘解磷定上下游产品
碘解磷定上游产品
碘解磷定下游产品
碘解磷定制备
氯解磷定置换得到。将氯解磷定加等量水,加热溶解,搅拌下滴加碘化钾饱和溶液,析出结晶,过滤,甩干。再用蒸馏水重结晶,活性炭脱色得碘解磷定。
碘解磷定文献
J. Appl. Toxicol. 35(2) , 219-27, (2014)
Unforeseen toxic effects contribute to compound attrition during preclinical evaluation and clinical trials. Consequently, there is a need to correlate in vitro toxicity to in vivo and clinical outcom...
Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications.Toxicol. Lett. 231(1) , 92-8, (2014)
Highly toxic organophosphorus (OP) nerve agents are well characterized regarding chemical, biological and toxicological properties and the effectiveness of standard atropine and oxime therapy. Open li...
An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.J. Biomol. Screen. 18(1) , 108-15, (2013)
Organophosphates are a class of highly toxic chemicals that includes many pesticides and chemical weapons. Exposure to organophosphates, either through accidents or acts of terrorism, poses a signific...
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