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盐酸依替福林

盐酸依替福林用途

盐酸阿替勒林是一种口服活性α肾上腺素能激动剂。盐酸依替勒林也是AMPK激活剂。盐酸依替勒林可用于体位性低血压的研究[1][2][3][4]。

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盐酸依替福林名称

[ CAS 号 ]:
943-17-9

[ 中文名 ]:
盐酸依替福林

[ 英文名 ]:
Efortil

[中文别名 ]:

[英文别名 ]:

etilefrine hydrochloride
Effortil
Thomasin
Effortil*HCl
EINECS 213-398-8
Etilefrin-HCl
Etilefrin dl-form hydrochloride
Cardanat
Etilefrine HCl
Effontil

盐酸依替福林生物活性

[ 描述 ]:

盐酸阿替勒林是一种口服活性α肾上腺素能激动剂。盐酸依替勒林也是AMPK激活剂。盐酸依替勒林可用于体位性低血压的研究[1][2][3][4]。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> AMPK

研究领域 >> 心血管疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK

[参考文献]

[1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24.

[2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5.

[3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24.

[4]. Bouaggad A, et al. The effect of oral etilefrine premedication on the incidence of hypotension during spinal anaesthesia. Eur J Anaesthesiol. 2000 Mar;17(3):177-81.

盐酸依替福林物理化学性质

[ 密度 ]:
1.127g/cm3

[ 沸点 ]:
351.7ºC at 760 mmHg

[ 熔点 ]:
122ºC

[ 分子式 ]:
C₁₀H₁₆ClNO₂

[ 分子量 ]:
217.69

[ 闪点 ]:
155.5ºC

[ 精确质量 ]:
217.086960

[ PSA ]:
52.49000

[ LogP ]:
2.22800

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride

盐酸依替福林MSDS

详细MSDS(安全技术说明书)

盐酸依替福林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO5618000

CHEMICAL NAME :: Benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-, hydrochloride

CAS REGISTRY NUMBER :: 943-17-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H15-N-O2.Cl-H

MOLECULAR WEIGHT :: 217.72

WISWESSER LINE NOTATION :: QR CYQ1M2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 187 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,187,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,225,1995

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,115,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

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盐酸依替福林安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
DO5618000

[ 海关编码 ]:
2922509090

盐酸依替福林上下游产品

盐酸依替福林上游产品

盐酸依替福林下游产品

盐酸依替福林海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

盐酸依替福林文献

Indications, surgical technique, and long-term experience with laparoscopic closure of the nephrosplenic space in standing horses.

Vet. Surg. 34(6) , 637-41, (2005)

To describe surgical technique and outcome after laparoscopic closure of the nephrosplenic space for treatment of recurrent left dorsal displacement of the left colon (LDDLC) in standing horses.Retros...

[A complicated course after esophagogastrectomy].

J. Chir. (Paris.) 144(3) , 241-5, (2007)

Priapism in a patient with unstable hemoglobin: hemoglobin Köln.

Am. J. Hematol. 74(1) , 73-4, (2003)

We report a case of severe priapism occurring in a patient with unstable hemoglobin, hemoglobin Köln, and underline several factors that may have contributed to this complication: abnormal plasticity ...

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