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(±)-Cromakalim

(±)-Cromakalim用途

Cromakalim是一种钾通道开放剂。克罗马卡林可作为支气管扩张剂治疗哮喘。克罗卡林以浓度相关的方式抑制人离体支气管的自发张力,几乎与异丙肾上腺素或茶碱一样有效[1]。

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(±)-Cromakalim名称

[ CAS 号 ]:
94470-67-4

[ 中文名 ]:
色满卡林

[ 英文名 ]:
Cromakalim

[英文别名 ]:

(+)-Cromakalim

(±)-Cromakalim生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 跨膜转运 >> 钾通道

[参考文献]

[1]. Cortijo J, et al. The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 1992;346(4):462-468.

(±)-Cromakalim物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
482.3±45.0 °C at 760 mmHg

[ 熔点 ]:
242-244ºC

[ 分子式 ]:
C₁₆H₂₀N₂O₃S

[ 分子量 ]:
286.33

[ 闪点 ]:
245.5±28.7 °C

[ 精确质量 ]:
286.131744

[ PSA ]:
73.56000

[ LogP ]:
1.27

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
-20°C，密闭，干燥

(±)-CromakalimMSDS

详细MSDS(安全技术说明书)

(±)-Cromakalim安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

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(±)-Cromakalim文献

The relaxant action of nicorandil in bovine tracheal smooth muscle.

Pharmacology 89(5-6) , 327-32, (2012)

The relaxant mechanisms of nicorandil were examined by comparing its effects with those of sodium nitroprusside and cromakalim in bovine tracheal smooth muscle. In preparations contracted with methach...

CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(10) , R1003-10, (2012)

Previously, we have shown that A(2A) adenosine receptor (A(2A)AR) mediates aortic relaxation via cytochrome P-450 (CYP)-epoxygenases. However, the signaling mechanism is not understood properly. We hy...

Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: effect of potassium channel modulators.

Eur. J. Pharmacol. 660(2-3) , 431-7, (2011)

Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+)...

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