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5-羟基噻苯咪唑

5-羟基噻苯咪唑用途

5-Hydroxythiabendazole(5-OHTBZ)是 Thiabendazole(HY-B0263)暴露的生物标志物。

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5-羟基噻苯咪唑名称

[ CAS 号 ]:
948-71-0

[ 中文名 ]:
噻苯咪唑-5-羟基

[ 英文名 ]:
5-hydroxy Thiabendazole

[中文别名 ]:

5-羟基噻苯咪唑

[英文别名 ]:

2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-ol

5-羟基噻苯咪唑生物活性

[ 描述 ]:

5-Hydroxythiabendazole(5-OHTBZ)是 Thiabendazole(HY-B0263)暴露的生物标志物。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. STONE OJ, et al. COMPARISON OF THIABENDAZOLE AND 5-HYDROXY-THIABENDAZOLE (FOR ANTHELMINTIC EFFECT). J Invest Dermatol. 1965 Aug;45:132-3.

5-羟基噻苯咪唑物理化学性质

[ 密度 ]:
1.535g/cm3

[ 沸点 ]:
525.6ºC at 760mmHg

[ 分子式 ]:
C₁₀H₇N₃OS

[ 分子量 ]:
217.25

[ 闪点 ]:
271.7ºC

[ 精确质量 ]:
217.03100

[ PSA ]:
90.04000

[ LogP ]:
2.39200

[ 折射率 ]:
1.783

[ 储存条件 ]:
0-6°C

5-羟基噻苯咪唑安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
22-50/53

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
UN 3077

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2934999090

5-羟基噻苯咪唑合成路线

详细合成路线

5-羟基噻苯咪唑上下游产品

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5-羟基噻苯咪唑下游产品

5-羟基噻苯咪唑海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-羟基噻苯咪唑文献

Multi-residue Determination of Polar Veterinary Drugs in Livestock and Fishery Products by Liquid Chromatography/Tandem Mass Spectrometry.

J. AOAC Int. 98(1) , 230-47, (2015)

Residues of 37 polar veterinary drugs belonging to six families (quinolones, tetracyclines, macrolides, lincosamides, sulfonamides, and others) in livestock and fishery products were determined using ...

Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells.

Chem. Biol. Interact. 127(2) , 109-24, (2000)

Thiabendazole (TBZ), an anthelmintic and fungicide benzimidazole, was recently demonstrated to be extensively metabolized by cytochrome P450 (CYP) 1A2 in man and rabbit, yielding 5-hydroxythiabendazol...

In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions.

Drug Metab. Dispos. 37 , 1286-1294, (2009)

Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2. Screen assays were carried out in the absence ...

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