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1-[4-(1,2,3,4-四羟基丁基)-1H-咪唑-2-基]乙酮

用途

2-乙酰-5-四羟基丁基咪唑是体内有效的鞘氨醇-1-磷酸(S1P)裂解酶抑制剂。

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名称

[ CAS 号 ]:
94944-70-4

[ 中文名 ]:
1-[4-(1,2,3,4-四羟基丁基)-1H-咪唑-2-基]乙酮

[ 英文名 ]:
2-ATHBI

[英文别名 ]:

2-Acetyl-4-tetrahydroxybutylimidazole
C9H14N2O5
2-Athbi

生物活性

[ 描述 ]:

2-乙酰-5-四羟基丁基咪唑是体内有效的鞘氨醇-1-磷酸(S1P)裂解酶抑制剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders. Med. Chem., 2009, 52 (13), pp 3941-3953

[2]. Schwab SR, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 9;309(5741):1735-9.

物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
613.5±65.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₁₄N₂O₅

[ 分子量 ]:
230.218

[ 闪点 ]:
324.8±34.3 °C

[ 精确质量 ]:
230.090271

[ PSA ]:
126.67000

[ LogP ]:
-3.67

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.635

[ 储存条件 ]:
-20°C，密闭，干燥

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933290090

海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment.

Antimicrob. Agents Chemother. 59 , 5664-74, (2015)

There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive...

Acoustic radiation force impulse with shear wave speed quantification of pancreatic masses: A prospective study.

Pancreatology 16 , 106-9, (2016)

Acoustic Radiation Force Impulse (ARFI) is a new ultrasound technique that evaluates mechanical properties of tissues. To evaluate the use of ARFI with shear waves speed quantification for pancreatic ...

Effect of oral and parenteral administration of B6 vitamers on the lymphopenia produced by feeding ammonia caramel or 2-acetyl-4(5)-(1,2,3,4-tetrahydroxy)butylimidazole to rats.

Food Chem. Toxicol. 27(10) , 627-30, (1989)

The ability of B6 vitamers to prevent the lymphopenic effects of ammonia caramel fed to rats has been evaluated. Diets containing 10 ppm pyridoxine or pyridoxal prevented the lymphopenia produced in r...

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