1-[4-(1,2,3,4-四羟基丁基)-1H-咪唑-2-基]乙酮
![1-[4-(1,2,3,4-四羟基丁基)-1H-咪唑-2-基]乙酮结构式](https://image.chemsrc.com/caspic/063/94944-70-4.png)
1-[4-(1,2,3,4-四羟基丁基)-1H-咪唑-2-基]乙酮结构式
|
常用名 | 1-[4-(1,2,3,4-四羟基丁基)-1H-咪唑-2-基]乙酮 | 英文名 | 2-ATHBI |
|---|---|---|---|---|
| CAS号 | 94944-70-4 | 分子量 | 230.218 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 613.5±65.0 °C at 760 mmHg | |
| 分子式 | C9H14N2O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 324.8±34.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
|
In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment.
Antimicrob. Agents Chemother. 59 , 5664-74, (2015) There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive multidrug combinations. Through the use of ordinary differ... |
|
|
Acoustic radiation force impulse with shear wave speed quantification of pancreatic masses: A prospective study.
Pancreatology 16 , 106-9, (2016) Acoustic Radiation Force Impulse (ARFI) is a new ultrasound technique that evaluates mechanical properties of tissues. To evaluate the use of ARFI with shear waves speed quantification for pancreatic masses characterization during the ultrasound examination.1... |
|
|
Effect of oral and parenteral administration of B6 vitamers on the lymphopenia produced by feeding ammonia caramel or 2-acetyl-4(5)-(1,2,3,4-tetrahydroxy)butylimidazole to rats.
Food Chem. Toxicol. 27(10) , 627-30, (1989) The ability of B6 vitamers to prevent the lymphopenic effects of ammonia caramel fed to rats has been evaluated. Diets containing 10 ppm pyridoxine or pyridoxal prevented the lymphopenia produced in rats consuming an 8% (w/v) solution of ammonia caramel, wher... |
|
|
Supercritical fluid extraction (SFE) of 4(5)-methylimidazole (4-MeI) and 2-acetyl-4(5)-(1,2,3,4)-tetrahydroxybutyl-imidazole (THI) from ground-coffee with high-performance liquid chromatographic-electrospray mass spectrometric quantification (HPLC/ESI-MS).
Food Addit. Contam. 23(10) , 963-73, (2006) Two polar analytes, 4(5)-methylimidazole (4-MeI) and 2-acetyl-4(5)-(1,2,3,4)-tetrahydroxybutyl-imidazole (THI), were extracted with supercritical carbon dioxide (CO2) modified with aqueous methanol. The method was applied to a roasted coffee powder with good ... |
|
|
Solid-phase extraction of 4(5)-methylimidazole (4MeI) and 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)-imidazole (THI) from foods and beverages with subsequent liquid chromatographic-electrospray mass spectrometric quantification.
J. Sep. Sci. 29(3) , 378-84, (2006) A method for the simultaneous determination of 4(5)-methylimidazole (4MeI) and 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)-imidazole (THI) was developed using SPE and HPLC/MS. Solid-phase extraction using SCX Disc cartridges was used for isolation of the analyt... |
|
|
Toxicity studies of Caramel Colour III and 2-acetyl-4(5)-tetrahydroxybutylimidazole in F344 rats.
Food Chem. Toxicol. 30(5) , 417-25, (1992) Caramel Colour III is used as a colour additive in beers and a variety of foods. Beer is the most important single source of Caramel Colour III in the diet although consumption of dark beers has been decreasing in recent years. The Joint FAO/WHO Expert Commit... |
|
|
Effects of subchronic exposure to Caramel Colour III on the immune system in mice.
Food Chem. Toxicol. 32(1) , 7-13, (1994) Administration of Caramel Colour III is associated with lymphopenia in laboratory animals, especially if the animals are fed a vitamin B6-deficient diet. Recently, functional immunological alterations in rats exposed to Caramel Colour III have been reported. ... |
|
|
Effects of 2-acetyl-4-tetrahydroxybutyl imidazole (THI) on the thymus of rats.
Thymus 20(1) , 17-30, (1992) 2-Acetyl-4-tetrahydroxybutyl imidazole (THI), a component of the food colouring ammonia caramel, has been shown to produce suppression of cell-mediated immunity and a reduction in circulating TH and TC/S lymphocytes in rats. Accordingly in this study the effe... |
|
|
Effect of pyridoxine on the disposition and lymphopenic effects of 2-acetyl-4(5)-tetrahydroxybutyl imidazole in the rat.
Xenobiotica 20(6) , 555-62, (1990) 1. 2-Acetyl-4(5)-tetrahydroxybutyl imidazole (THI) administered orally to rats markedly decreased the peripheral blood lymphocyte count within 16-24 h. The lymphopenic effect of THI was prevented by co-administration of pyridoxine. 2. 14C-THI, administered or... |
|
|
Immunosuppressive effects of 2-acetyl-4-tetrahydroxybutyl imidazole (THI) in the rat.
Clin. Exp. Immunol. 85(2) , 335-40, (1991) THI is a component of ammonia caramel, a widely used food colouring. The effect of THI on the immune system has been determined in the male F344 rat. THI was given in the drinking water at doses of 1, 10 and 50 mg/l (equivalent to 0.1, 1 and 5 mg/kg per day) ... |