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2,4-二氨基甲苯

2,4-二氨基甲苯用途

【用途一】
用于制取TDI、硫化染料、碱性染料、分散染料、医药中间体及其他有机合成的中间体
【用途二】
有机合成中间体。用于生产甲苯二异氰酸酯，染料毛皮黑DB、硫化黄棕5G、硫化黄棕6G、硫化红棕B3R等。制成的染料可使皮毛、头发直接氧化成黑色。
【用途三】
是有机合成原料之一，可制取甲苯二异氰酸酯。也用作染料中间体、毛发染黑
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2,4-二氨基甲苯名称

[ CAS 号 ]:
95-80-7

[ 中文名 ]:
2,4-二氨基甲苯

[ 英文名 ]:
2,4-Diaminotoluene

[中文别名 ]:

[英文别名 ]:

2,4-二氨基甲苯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
292.0±0.0 °C at 760 mmHg

[ 熔点 ]:
97-99 °C(lit.)

[ 分子式 ]:
C7H10N2

[ 分子量 ]:
122.168

[ 闪点 ]:
149.5±21.3 °C

[ 精确质量 ]:
122.084396

[ PSA ]:
52.04000

[ LogP ]:
0.15

[ 外观性状 ]:
无色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.636

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂、酸类分开存放

[ 水溶解性 ]:
50 g/l (25 ºC)

2,4-二氨基甲苯MSDS

详细MSDS(安全技术说明书)

2,4-二氨基甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XS9625000
CHEMICAL NAME :
Toluene-2,4-diamine
CAS REGISTRY NUMBER :
95-80-7
BEILSTEIN REFERENCE NO. :
2205839
LAST UPDATED :
199712
DATA ITEMS CITED :
64
MOLECULAR FORMULA :
C7-H10-N2
MOLECULAR WEIGHT :
122.19
WISWESSER LINE NOTATION :
ZR CZ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8050 mg/kg/101W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5030 mg/kg/84W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9000 mg/kg/36W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8400 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1260 mg/kg
SEX/DURATION :
male 10 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1260 mg/kg
SEX/DURATION :
male 10 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
210 mg/kg
SEX/DURATION :
male 1 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1200 mg/kg
SEX/DURATION :
female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
DNA adduct
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 135,115,1984 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,83,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,83,1978 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TOLUENEDIAMINE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5386 No. of Facilities: 130 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 8511 (estimated) No. of Female Employees: 396 (estimated)
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2,4-二氨基甲苯安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312-H317-H341-H350-H361f-H373-H411

[ 警示性声明 ]:
P201-P273-P280-P301 + P310-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R21;R25;R36;R43;R45;R51/53

[ 安全声明 (欧洲) ]:
S53-S45-S61

[ 危险品运输编码 ]:
UN 1709 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
XS9625000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29331990

2,4-二氨基甲苯合成路线

详细合成路线

2,4-二氨基甲苯上下游产品

2,4-二氨基甲苯上游产品

2,4-二氨基甲苯下游产品

2,4-二氨基甲苯制备

由对硝基甲苯用混酸硝化得2,4-二硝基甲苯，然后用铁粉还原得粗品，再经浓缩、蒸馏得成品。生产工艺如下：（1）硝化 将熔化的对硝基甲苯（100%，643.9kg)小心送入硝化釜中（釜中预先放有废酸94.7kg，废酸中硫酸含量约77%。第一次硝化无废酸，可用相当浓度的硫酸代替），搅拌并使釜内温度冷却至（55±2）℃然后细流注入混酸316.2kg（混酸组成：硝酸31.75%，硫酸64.85%，水3.4%。脱水值=5）。第一阶段加入一半混酸，加料温度52-56℃；第二阶段加佘下的一半混酸，温度自54℃逐渐提升到70℃，混酸加完后控制温度在（70±2）℃。加混酸时间视反应温度而定，一般约6-7h。混酸加毕，升温到75℃，保温搅拌2.25h测定终点，以凝固点达到67℃以上为合格。在搅拌下细心地徐徐加入冷水70L进行稀释，温度控制在75-77℃，水加完后搅拌15min。停止搅拌，静置0.5h，然后插入塑料管直至釜底，冷却至室温，在冷却过程中，请注意凝结，在将要凝结成固体时，要小心不断地转动塑料管并勿使液体搅浑。待反应物全部凝固。拔出塑料管，放去废酸，加热使反应物重新熔化，温度不超过80℃。熔毕，停止加热，搅拌3-5min后，静置30min，冷却，并插入塑料管，如上法，待完全凝结后，拔去塑料管，放尽废酸，再加热熔化，温度不超过80℃反应物为黄色油状物，在75℃保温。于精制釜内放水1300L，升温至68-70℃，在搅拌下细流注入黄色油状物，随时加入液碱进行中和，严格控制PH=5-6。使反应物温度在67-68℃，即喷入冷水进行降温，有黄色针状结晶出，继续搅拌冷却到35℃左右，放料过滤，滤饼用喷淋冷水洗涤，得黄色结晶的2，4-二硝基甲苯。 （2）还原 于还原釜中加入水1300L，在搅拌下先加入铁粉500kg，加热到70℃后，再加30%盐酸40kg，升温到90-95℃，取样滴于滤纸上，润圈与5%硫化碱液相交处有黑色出现，即可开始分批加入二硝基甲苯（100%364kg），使反应剧烈进行，保持100-102℃的沸腾状态。加料时要随时检查，取样滴于滤纸上无黄色润留，与5%硫化碱液相交处显黑色，与石蕊试纸应显红色。待二硝基甲苯加入总量的75%后，再测试终点。危重再将铁粉100kg同料交叉加入，全部加料时间为1-1.5h，始终保持沸腾，料加完再搅拌0.5h，以反应液在滤纸上润圈不显黄色为终点。还原终点到后，停止加热，降温到85-90℃，小心加入用石灰30kg及水调成的石灰浆，使PH值为8-9，然后加入50%硫化碱5kg，继续搅拌15min，以料液在滤纸上润圈与5%硫化碱液相交无黑色痕迹为中和终点。中和毕，再加入亚硫酸钠2kg，搅拌15min，静置0.5h，使铁泥充分沉淀。 (3)过滤、浓缩 铁泥沉降后，将上层清液吸入贮槽中，残留在还原釜中的铁泥加水1000-1200L，搅拌升温到95℃静置0.5h，然后将上层洗涤清液吸入贮槽中，如上法反复进行三次洗涤，洗液均合并还原母液中进行吸滤；吸滤后，料液在真空度80kg下蒸发浓缩，约6h完成。 （4）减压蒸馏 将浓缩液吸到蒸馏釜中，在真空度74.7-90.7kpa，夹层油温180-210℃，顶温50-60℃，搅拌下，进行脱水。当真空度上升到94.7-97.3kpa，顶温为190-200℃，夹层油温为280-290℃下进行蒸馏，随着蒸馏釜内物料减少，真空逐渐上升，顶温逐渐下降到170-180℃，油温提高到300-320℃左右，此时可认为蒸馏已到终点。每批操作得成品约500kg。 原料消耗定额：对硝基甲苯1600kg/t、硫酸（98%）1616kg/t、硝酸（98%）760kg/t、铁粉（90%）2700kg/t。
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2,4-二氨基甲苯海关

[ 海关编码 ]: 2921519020

[ 中文概述 ]:
2921519020 2,4-二氨基甲苯。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:17.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: X.有毒化学品环境管理放行通知单

[ Summary ]:
2921519020 4-methylbenzene-1,3-diamine。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:17.0%。MFN tarrif:6.5%。general tariff:30.0%

2,4-二氨基甲苯文献

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

Eur. J. Med. Chem. 44 , 3658-64, (2009)

A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment.

Regul Toxicol Pharmacol 44(2) , 161-71, (2006)

This paper describes the applicability of in vitro digestion models as a tool for consumer products in (ad hoc) risk assessment. In current risk assessment, oral bioavailability from a specific produc...

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.

Mutat. Res. Genet. Toxicol. Environ. Mutagen. 786-788 , 3-13, (2015)

The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally va...


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￥258.0/500g ￥88.0/100g

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【2,4-二氨基甲苯】化源网提供2,4-二氨基甲苯CAS号95-80-7，2,4-二氨基甲苯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询2,4-二氨基甲苯上化源网，专业又轻松。>>电脑版：2,4-二氨基甲苯

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