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1,2,3-丙烷三甲酸

1,2,3-丙烷三甲酸用途

Tricarballylic acid 是一种三碳烯丙酸酯的共轭酸,是乌头酸水合酶 (aconitate hydratase) 的竞争性抑制剂,其 Ki 值为 0.52 mM。

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1,2,3-丙烷三甲酸名称

[ CAS 号 ]:
99-14-9

[ 中文名 ]:
丙三羧酸

[ 英文名 ]:
Tricarballylic acid

[中文别名 ]:

[英文别名 ]:

EINECS 202-733-3
Propane 1,2,3-tricarboxylic acid
3-Carboxyglutaric acid
Carballylic acid
tricarballylic acid
3-Carboxypentane-1,5-dioic acid
MFCD00002723
Propane-1,2,3-tricarboxylic acid
QV1YVQ1VQ
1,2,3-Propanetricarboxylic acid

1,2,3-丙烷三甲酸生物活性

[ 描述 ]:

Tricarballylic acid 是一种三碳烯丙酸酯的共轭酸,是乌头酸水合酶 (aconitate hydratase) 的竞争性抑制剂,其 Ki 值为 0.52 mM。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[ 靶点 ]

Ki: 0.52 mM (aconitate hydratase)[1]

[参考文献]

[1]. Russell, James B.; Forsberg, Neil (2007). "Production of tricarballylic acid by rumen microorganisms and its potential toxicity in ruminant tissue metabolism". British Journal of Nutrition. 56 (1): 153–62.

1,2,3-丙烷三甲酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
266.4±20.0 °C at 760 mmHg

[ 熔点 ]:
156-161 °C(lit.)

[ 分子式 ]:
C₆H₈O₆

[ 分子量 ]:
176.124

[ 闪点 ]:
129.2±18.3 °C

[ 精确质量 ]:
176.032089

[ PSA ]:
111.90000

[ LogP ]:
-1.33

[ 外观性状 ]:
灰白色至淡棕色细结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
室温，密封，干燥

[ 水溶解性 ]:
H2O: 50 mg/mL, clear

1,2,3-丙烷三甲酸MSDS

1,2,3-丙烷三甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2917190090

1,2,3-丙烷三甲酸合成路线

1,2,3-丙烷三甲酸上下游产品

1,2,3-丙烷三甲酸上游产品

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1,2,3-丙烷三甲酸海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

1,2,3-丙烷三甲酸文献

Enhanced shRNA delivery and ABCG2 silencing by charge-reversible layered nanocarriers.

Small 11(8) , 952-62, (2015)

Polycationic vectors have been used to deliver short hairpin RNAs (shRNAs) to knock-down genes for cancer therapies, but their inefficiency in lysosomal escape and shRNA release causes their low gene ...

Citrate modulates lipopolysaccharide-induced monocyte inflammatory responses.

Clin. Exp. Immunol. 180 , 520-30, (2015)

Citrate, a central component of cellular metabolism, is a widely used anti-coagulant due to its ability to chelate calcium. Adenosine triphosphate (ATP)-citrate lyase, which metabolizes citrate, has b...

Reactions of atomic metal anions in the gas phase: competition between electron transfer, proton abstraction and bond activation.

J. Phys. Chem. A 115(48) , 14006-12, (2011)

Bare metal anions K(-), Rb(-), Cs(-), Fe(-), Co(-), Ni(-), Cu(-), and Ag(-), generated by electrospray ionization of the corresponding oxalate or tricarballylate solutions, were allowed to react with ...

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