A3N19

• 常用名: A3N19
• 英文名: A3N19
• CAS号: 2249755-49-3
• 分子量: 593.70
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₃₁N₉O₂S
• 熔点: N/A
• 闪点: N/A

A3N19用途

A3N19是一种有效的HIV-1非核苷逆转录酶抑制剂,对HIV-1 IIIB的EC50为3.28 nM【1】。

A3N19名称

• 英文名: A3N19

A3N19生物活性

• 描述: A3N19是一种有效的HIV-1非核苷逆转录酶抑制剂,对HIV-1 IIIB的EC50为3.28 nM【1】。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Kang D, et, al. In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP. Eur J Med Chem. 2020 May 1;193:112237.

A3N19物理化学性质

• 分子式: C₃₁H₃₁N₉O₂S
• 分子量: 593.70
• InChIKey: VXMHGGPCMIWHJI-UHFFFAOYSA-N
• SMILES: Cc1cc(C#N)cc(C)c1Oc1nc(NC2CCN(Cc3cn(Cc4ccc(C(N)=O)cc4)nn3)CC2)nc2ccsc12

A3N19靶点实验

查看更多实验

实验名称：Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction ... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL4686445

实验名称：Inhibition of HIV-1 reverse transcriptase assessed as reduction in biotin-dUTP incorp... 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL4686444

实验名称：Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 5 ... 来源：ChEMBL 靶标：MT4 External Id：CHEMBL4686447

实验名称：Antiviral activity against HIV1 RES056 infected in human MT4 cells assessed as reduct... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL4686446

实验名称：Selectivity index, ratio of CC50 for cytotoxicity against human MT4 cells to EC50 for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4686449

实验名称：Selectivity index, ratio of CC50 for cytotoxicity against human MT4 cells to EC50 for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4686448

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