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地拉夫定甲磺酸盐

地拉夫定甲磺酸盐用途

Delavirdine mesylate是有效的非核苷 HIV-1 逆转录酶抑制剂 (NNRTI)。

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地拉夫定甲磺酸盐名称

[ CAS 号 ]:
147221-93-0

[ 中文名 ]:
地拉夫定甲磺酸盐

[ 英文名 ]:
DELAVIRDINE MESYLATE

[英文别名 ]:

DELAVIRDINE, MESYLATE
delavirdine mesilate [INN_en]
DELAVIRDINE MESYLATE
Delavirdine monomethanesulfonate
Delavirdine (mesylate)

地拉夫定甲磺酸盐生物活性

[ 描述 ]:

Delavirdine mesylate是有效的非核苷 HIV-1 逆转录酶抑制剂 (NNRTI)。

[ 相关类别 ]:

信号通路 >> 抗感染 >> HIV

信号通路 >> 抗感染 >> 逆转录酶

研究领域 >> 感染

[参考文献]

[1]. Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.

[2]. Voorman RL, et al. Interaction of delavirdine with human liver microsomal cytochrome P450: inhibition of CYP2C9, CYP2C19, and CYP2D6. Drug Metab Dispos. 2001 Jan;29(1):41-7.

[3]. Shelton MJ, et al. Pharmacokinetics of ritonavir and delavirdine in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 2003 May;47(5):1694-9.

[相关活性小分子]

地拉夫定甲磺酸盐物理化学性质

[ 沸点 ]:
732ºC at 760mmHg

[ 熔点 ]:
118-120ºC

[ 分子式 ]:
C₂₃H₃₂N₆O₆S₂

[ 分子量 ]:
552.667

[ 闪点 ]:
396.5ºC

[ 精确质量 ]:
552.182495

[ PSA ]:
181.56000

[ LogP ]:
4.53160

[ 蒸汽压 ]:
2.74E-21mmHg at 25°C

[ 储存条件 ]:
2-8℃

地拉夫定甲磺酸盐MSDS

详细MSDS(安全技术说明书)

地拉夫定甲磺酸盐安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

地拉夫定甲磺酸盐文献

Colloid formation by drugs in simulated intestinal fluid.

J. Med. Chem. 53 , 4259-65, (2010)

Many organic molecules form colloidal aggregates in aqueous solution at micromolar concentrations. These aggregates promiscuously inhibit soluble proteins and are a major source of false positives in ...

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Colloids Surf. B Biointerfaces 90 , 75-82, (2012)

Graphical abstract

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.

Bioorg. Med. Chem. 21(7) , 2128-34, (2013)

In continuation of our efforts toward identification and optimization of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs), we have employed a structure-based bioisosterism strategy, with...

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