< 生产厂家价格 >

依布硒

依布硒用途

Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。

点击显示

依布硒名称

[ CAS 号 ]:
60940-34-3

[ 中文名 ]:
依布硒

[ 英文名 ]:
Ebselen

[中文别名 ]:

[英文别名 ]:

2-Phenyl-1,2-benzoselenazol-3(2H)-one
1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-
Ebselenum
2-phenyl-1,2-benzoselenazol-3-one
Harmokisane
Ebselen
MFCD00210937
Ebseleno
Ebselene

依布硒生物活性

[ 描述 ]:

Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 抗感染 >> HIV

研究领域 >> 炎症/免疫

[参考文献]

[1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.

[2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.

[相关活性小分子]

依布硒物理化学性质

[ 沸点 ]:
402.8±28.0 °C at 760 mmHg

[ 熔点 ]:
178-181 °C

[ 分子式 ]:
C₁₃H₉NOSe

[ 分子量 ]:
274.177

[ 闪点 ]:
197.4±24.0 °C

[ 精确质量 ]:
274.984924

[ PSA ]:
22.00000

[ LogP ]:
2.04770

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 储存条件 ]:
2-8°C

依布硒MSDS

详细MSDS(安全技术说明书)

依布硒毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4140750

CHEMICAL NAME :: 1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-

CAS REGISTRY NUMBER :: 60940-34-3

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H9-N-O-Se

MOLECULAR WEIGHT :: 274.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

点击显示

依布硒安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H331-H373-H410

[ 警示性声明 ]:
P261-P273-P301 + P310-P311-P501

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/25;R33;R50/53

[ 安全声明 (欧洲) ]:
S20/21-S28-S45-S60-S61-S28A

[ 危险品运输编码 ]:
UN 3283 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DE4140750

[ 海关编码 ]:
2927000090

依布硒制备

1. 2,2’-二硒化二苯甲酸的制备

在反应瓶中加入KOH7.1g(0.13mol)、水18ml和85%水合肼3.2g(0.05mol),于60~70ºC搅拌均匀后分批加入硒粉10g(0.13mol),于70ºC搅拌反应1h.室温下加入由2-氨基苯甲酸17.3g(0.13mol)和亚硝酸钠11.1g(0.16mol)制得的重氮盐溶液.加毕,于60ºC搅拌反应2h.降至室温,用6mol/L盐酸调至pH<1,过滤,滤饼水洗后得红褐色固体.转至1mol/LNa2CO3溶液中,煮沸后滤除不溶物,用1mol/L盐酸调至pH<1,过滤,滤饼水洗后抽干,干燥,得淡黄色固体2,2’-二硒化二苯甲酸22.8g,收率90.1%,mp295~296 ºC.

2. 2-氯硒苯甲酰氯的制备

在反应瓶中加入2,2’-二硒化二苯甲酸6.0g(0.02mol)和SOCl2,剩余物用正己烷重结晶,得浅黄色固体2-氯硒苯甲酰氯6.25g,收率82%,mp63~64ºC.

3. 依布硒的合成

在反应瓶中加入苯胺3ml(0.03mol)和乙醚30ml,搅拌下滴加2-氯硒苯甲酰氯[3.0g(0.01mol)]的乙醚(40ml)溶液,滴加过程控制温度不超过室温(一般25 ºC).加毕,搅拌3h.减压蒸除溶剂,剩余物用快速柱色谱分离[硅胶G,流动相为乙酸乙酯/氯仿(1:2)].蒸除溶剂后得淡黄色固体依布硒3.0g,收率92.6%,mp179~180 ºC.

点击显示

依布硒海关

[ 海关编码 ]: 2927000090

[ 中文概述 ]:
2927000090 其他重氮化合物、偶氮化合物等（包括氧化偶氮化合物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

依布硒文献

Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts.

Int. Arch. Allergy Immunol. 159(3) , 278-86, (2012)

Myofibroblasts are detected in nasal polyps and are involved in nasal polyp formation by inducing extracellular matrix accumulation. Reactive oxygen species (ROS) are released during the differentiati...

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

J. Exp. Med. 212(4) , 555-68, (2015)

The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its re...

Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.

Mol. Cell. Neurosci. 67 , 116-25, (2015)

Previous studies have shown that bone morphogenetic proteins (BMPs) promote dendritic growth in sympathetic neurons; however, the downstream signaling molecules that mediate the dendrite promoting act...

更多文献

依布硒

依布硒用途

依布硒名称

依布硒生物活性

依布硒物理化学性质

依布硒MSDS

详细MSDS(安全技术说明书)

依布硒毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

依布硒安全信息

依布硒制备

依布硒海关

依布硒文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物