补骨脂定

Zhongguo Zhong Yao Za Zhi 38(11) , 1816-9, (2013)

To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism.Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group, the model group, the psoralidine low-dose group (4 mg x kg(-1)), the ps...

Zhong Yao Cai 34(8) , 1211-3, (2011)

To study the chemical constituents of Psoralea corylifolia.Column chromatography was used in the isolation procedure. The structures of isolated compounds were elucidated by spectral data.Seven compounds were isolated and their structures were identified as i...

Biochem. Pharmacol. 82(5) , 524-34, (2011)

Radiotherapy is the most significant non-surgical cure for the elimination of tumor, however it is restricted by two major problems: radioresistance and normal tissue damage. Efficiency improvement on radiotherapy is demanded to achieve cancer treatment. We f...

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 821(1) , 67-74, (2005)

High-performance liquid chromatography (HPLC) was developed for fingerprint analysis of Psoralea corylifolia. Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn) technique was first employed to identify the components of the fi...

Prog. Neuropsychopharmacol. Biol. Psychiatry 32(2) , 510-9, (2008)

The antidepressant-like effects of psoralidin isolated from the seeds of Psoralea corylifolia were investigated in the forced swimming test (FST) in ICR strain of male mice. Psoralidin significantly decreased immobility time and increased swimming behavior wi...

J. Org. Chem. 74(7) , 2750-4, (2009)

A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological a...

Eur. J. Pharmacol. 650(1) , 102-9, (2011)

Psoralidin has been reported to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production, but the mechanisms of the action remain unclear. Thus, the impact of psoralidin on signaling pathways known to be implicated in NO synthesis was explored in...

Pharmacol. Rep. 63(1) , 139-48, (2011)

Numerous compounds detected in medical plants and dietary components or supplements possess chemopreventive, antitumor and immunomodulatory properties. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an important endogenous anticancer facto...

J. Sep. Sci. 30(6) , 813-8, (2007)

Fructus Psoraleae, a widely used traditional Chinese medicine, is well known as a health supplement ingredient. In our study, an improved and comprehensive HPLC fingerprint of Fructus Psoraleae was established. Two important new benzofuran glycosides, psorale...

Mol. Cancer Ther. 9(9) , 2488-96, (2010)

Epidermal growth factor receptor (EGFR) activation is an important event that regulates mitogenic signaling, such as the Raf, mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 cascades. EGFR activation has been implicated ...