聚乙二醇单甲醚
聚乙二醇单甲醚结构式
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常用名 | 聚乙二醇单甲醚 | 英文名 | m-PEG-OH (MW 2000) |
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| CAS号 | 9004-74-4 | 分子量 | 516.620 | |
| 密度 | 1.08 | 沸点 | 557.1±45.0 °C at 760 mmHg | |
| 分子式 | C23H48O12 | 熔点 | 12 ºC | |
| MSDS | 中文版 美版 | 闪点 | 268 ºC |
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Universal concept for the implementation of a single cleavable unit at tunable position in functional poly(ethylene glycol)s.
Biomacromolecules 14(2) , 448-59, (2013) Poly(ethylene glycol) (PEG) with acid-sensitive moieties gained attention particularly for various biomedical applications, such as the covalent attachment of PEG (PEGylation) to protein therapeutics, the synthesis of stealth liposomes, and polymeric carriers... |
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Preliminary assessment of the safety evaluation of novel pH-sensitive hydrogel.
Eur. J. Pharm. Biopharm. 82(2) , 332-9, (2012) In our previous work, a new kind of pH-sensitive hydrogel based on poly (lactic acid) (PLA), methoxyl poly (ethylene glycol) (MPEG) and itaconic acid (IA) was prepared by heat-initiated free radical polymerization without any organic solvent. For further appl... |
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PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice.
J. Virol. 87(7) , 3752-9, (2013) We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using... |
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How a simple "clicked" PEGylated 1,2,3-triazole ligand stabilizes gold nanoparticles for multiple usage.
Chem. Commun. (Camb.) 49(31) , 3218-20, (2013) "Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible application... |
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Characterization of biomolecular nanoconjugates by high-throughput delivery and spectroscopic difference.
Nanomedicine (Lond.) 7(12) , 1851-62, (2012) Nanoparticle conjugates have the potential for delivering siRNA, splice-shifting oligomers or nucleic acid vaccines, and can be applicable to anticancer therapeutics. This article compares tripartite conjugates with gold nanoparticles or synthetic methoxypoly... |
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(pGlu-Gln)-CCK-8[mPEG]: a novel, long-acting, mini-PEGylated cholecystokinin (CCK) agonist that improves metabolic status in dietary-induced diabetes.
Biochim. Biophys. Acta 1830(8) , 4009-16, (2013) Cholecystokinin (CCK) is a gastrointestinal hormone that has been proposed as a potential therapeutic option for obesity-diabetes. As such, (pGlu-Gln)-CCK-8 is an N-terminally modified CCK-8 analogue with improved biological effectiveness over the native pept... |
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CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes.
Colloids Surf. B Biointerfaces 105 , 31-6, (2013) This research is aimed to develop a nano-sized supramolecular micelle delivery system of cis-dichlorodiammine platinum (II) (CDDP) in order to achieve the passive tumor targeting. Firstly, star-shaped poly (γ-benzyl-L-glutamate) was synthesized by the ring-op... |
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Facile surface PEGylation via tyrosinase-catalyzed oxidative reaction for the preparation of non-fouling surfaces.
Colloids Surf. B Biointerfaces 102 , 585-9, (2013) The control of biological interactions that occur at material-cell/blood interfaces is of great importance to help maximize in vitro and in vivo performance of biomedical devices. PEGylation has been extensively used as an effective surface modification tool ... |
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Microcosmic mechanisms for protein incomplete release and stability of various amphiphilic mPEG-PLA microspheres.
Langmuir 28(39) , 13984-92, (2012) The microcosmic mechanisms of protein (recombinant human growth hormone, rhGH) incomplete release and stability from amphiphilic poly(monomethoxypolyethylene glycol-co-D,L-lactide) (mPEG-PLA, PELA) microspheres were investigated. PELA with different hydrophil... |
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Improved thermal cycling durability and PCR compatibility of polymer coated quantum dot.
Nanotechnology 24(35) , 355504, (2013) Quantum dots have experienced rapid development in imaging, labeling and sensing in medicine and life science. To be suitable for polymerase chain reaction (PCR) assay, we have tested QD thermal cycling durability and compatibility, which have not been addres... |