SKF83959
SKF83959结构式
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常用名 | SKF83959 | 英文名 | SKF 83959 HYDROBROMIDE |
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| CAS号 | 80751-85-5 | 分子量 | 398.72200 | |
| 密度 | 1.249g/cm3 | 沸点 | 464.6ºC at 760 mmHg | |
| 分子式 | C18H21BrClNO2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 234.8ºC |
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SKF83959 is a potent allosteric modulator of sigma-1 receptor.
Mol. Pharmacol. 83(3) , 577-86, (2013) SKF83959 (3-methyl-6-chloro-7,8-hydroxy-1-[3-methylphenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine), an atypical dopamine receptor-1 (D(1) receptor) agonist, has shown many D(1) receptor-independent effects, such as neuroprotection, blockade of Na(+) channel, and... |
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The D₁ dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways.
Mol. Vis. 18 , 2882-95, (2012) Oxidative stress is widely implicated in the death of retinal ganglion cells associated with various optic neuropathies. Agonists of the dopamine D(1) receptor have recently been found to be potentially neuroprotective against oxidative stress-induced injury.... |
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Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses.
Neuropharmacology 57(2) , 164-71, (2009) Recent work has demonstrated that a phosphatidylinositol (PI)-linked D(1) dopamine receptor selective agonist, SKF83959, mediates phosphatidylinositol hydrolysis via activation of phospholipase C(beta) in brain. Specific contributions of SKF83959 to synaptic ... |
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Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959.
Eur. J. Pharmacol. 632(1-3) , 39-44, (2010) This study applies new magnetic sensor-electromyographic technology for recording jaw movements in freely moving rats to analyse topographies of orofacial movement that occur in association with individual elements of behaviour under challenge with two dopami... |
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Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum.
J. Neurochem. 107(4) , 1014-26, (2008) Dopamine D(1)-like receptors play a key role in dopaminergic signaling. In addition to G(s/olf)/adenylyl cyclase (AC)-coupled D(1) receptors, the presence of D(1)-like receptors coupled to G(q)/phospholipase C (PLC) has been proposed. Benzazepine D(1) recepto... |
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Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study.
J. Lipid Res. 50(3) , 405-11, (2009) To investigate the effects of omega-3 fatty acid deficiency on phosphatidylinositol signaling in brain, myo-inositol (mI) concentrations were determined in the prefrontal cortex (PFC) of omega-3 fatty acid deficient rats by in vivo proton magnetic resonance s... |
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Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice.
Prog. Neuropsychopharmacol. Biol. Psychiatry 33(2) , 330-3, (2009) Studies in antipsychotic-naïve patients with schizophrenia indicate a baseline level of spontaneous involuntary movements, particularly orofacial dyskinesia. Neuregulin-1 is associated with risk for schizophrenia and its functional role can be studied in 'kno... |
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Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons.
J. Neurophysiol. 101(5) , 2230-8, (2009) Recent evidences indicate the existence of a putative novel phosphatidylinositol (PI)-linked D(1) dopamine receptor that mediates excellent anti-Parkinsonian but less severe dyskinesia action. To further understand the basic physiological function of this rec... |
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Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities.
Bioorg. Med. Chem. 16(21) , 9425-31, (2008) A series of racemic 6-aryl substituted 1-phenylbenzazepines 7a-e, and 17a,b were prepared. All these compounds showed binding potencies compatible to or much higher than that of the prototypic (+/-)-SKF-38393 ((+/-)-1) and (+/-)-SKF-83959 (3) for the D(1) rec... |
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Dopamine D1 receptor signaling: does GαQ-phospholipase C actually play a role?
J. Pharmacol. Exp. Ther. 351(1) , 9-17, (2014) Despite numerous studies showing therapeutic potential, no central dopamine D1 receptor ligand has ever been approved, because of potential limitations, such as hypotension, seizures, and tolerance. Functional selectivity has been widely recognized as providi... |