淫羊藿苷

Neuroscience 236 , 281-8, (2013)

Post-stroke dementia (PSD) is a common clinical disease and the central cholinergic circuits are important to cognitive function. Icariin (ICA), a flavonoid isolated from Herba Epimedii, was reported to improve cognitive function through modulating the cholin...

Biosci. Biotechnol. Biochem. 76(5) , 923-7, (2012)

This study characterizes the correlation between the chemical fingerprint and estrogenic activity of an Epimedium koreanum extract. The estrogenic activity of 31 E. koreanum extract samples was evaluated by a luciferase reporter gene assay, and the samples we...

J. Surg. Res. 192(2) , 447-53, (2014)

Wear particle-induced periprosthetic osteolysis that results in aseptic loosening is the most common cause of long-term failure after total joint replacement.Icariin (ICA), a flavonoid isolated from Epimedium pubescens, inhibits osteoclast formation, but its ...

Bone 51(1) , 85-92, (2012)

Osteoprogeterin (OPG) plays an important role in regulating bone homeostasis by inhibiting osteoclastogenesis and bone resorption. Icariin is the major ingredient of Herba Epimedii, which exerts anabolic and anti-resorptive effects on bone, but the mechanism ...

Osteoarthr. Cartil. 20(12) , 1647-56, (2012)

To investigate whether icariin, which is a widely used pharmacological constituent in traditional Chinese herbal medicine, can be a potential promoting compound for cartilage tissue engineering.Icariin was added into cell-hydrogel constructs derived from neon...

Psychoneuroendocrinology 38(1) , 122-34, (2013)

Epidemiological evidence demonstrates the neuroendocrine link between stress, depression and diabetes. This study observed glucose intolerance of rats exposed to chronic unpredictable mild stress (CUMS) in oral glucose tolerance test (OGTT). CUMS procedure si...

Biochem. Pharmacol. 85(6) , 798-807, (2013)

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestine which involves overproduction of pro-inflammatory cytokines and excessive functions of inflammatory cells. However, current treatments for IBD may have potential adverse effe...

Biochimie 94(12) , 2514-22, (2012)

Accumulating evidences suggest that Herba epimedii has the potential benefits against osteoporosis. However, previous studies were focused on the crude extract, total flavonoids (TF) and icariin (ICA), and the detailed molecular mechanisms of action and struc...

Int. J. Nanomedicine 7 , 4239-49, (2012)

Icariin is a bioactive herbal ingredient isolated from Herba epimedii, which has been widely used for the treatment of osteoporosis and male sexual dysfunction in traditional Chinese medicine. The major objective of this work is to investigate the different e...

Int. J. Mol. Med. 30(4) , 889-95, (2012)

Icariin, the main active compound of the traditional Chinese medicine, Epimedium, is commonly used for the clinical treatment of osteoporosis. However, the precise molecular mechanism of the therapeutic effect of icariin has not been elucidated. The aim of th...