FPL 55712
FPL 55712结构式
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常用名 | FPL 55712 | 英文名 | FPL 55712 |
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| CAS号 | 40786-08-1 | 分子量 | 520.50400 | |
| 密度 | 1.314g/cm3 | 沸点 | 716.9ºC at 760 mmHg | |
| 分子式 | C27H29NaO9 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 238.2ºC |
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Strategies in the design of peptidoleukotriene antagonists.
J. Lipid Mediat. 6(1-3) , 265-73, (1993) The research of the last two decades in the field of SRS-A and peptidoleukotriene (pLT) antagonists has provided information for the design of potent pLT antagonists, which share some or all of the following structural elements: (1) a lipophilic anchor, which... |
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Leukotriene receptor blockade in experimental heart failure.
Res. Exp. Med. (Berl.) 197(4) , 177-87, (1997) The pathophysiological role of endogenous leukotrienes in cardiovascular control and the regulation of renal function in congestive heart failure is not known. Therefore, in six conscious dogs with or without heart failure induced by right ventricular pacing ... |
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Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
Inflamm. Res. 46 Suppl 1 , S93-4, (1997)
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Effects of atropine, acetylsalicylic acid, FPL 55712, and phentolamine on increased histamine responsiveness of cat lung strips under conditions of airway inflammation.
Eur. Respir. J. 2(6) , 517-21, (1989) Our recent in vitro studies on airway smooth muscles of cats with turpentine oil inflammation showed an increase of isometric tension of the lung strips to histamine application. This communication describes the effect of atropine, acetylsalicylic acid, FPL 5... |
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In vitro effect of DP-1904, a novel anti-asthma agent, against antigen-induced constriction and TXB2 release from the isolated guinea-pig lung parenchymal tissue.
Pharmacol. Res. 38(2) , 141-7, (1998) The contractile activity and mobilisation of arachidonic acid metabolites in response to the antigen challenge were studied in isolated lung parenchymal tissue from the actively sensitised guinea pig. The sustained constriction of the lung tissue was evoked b... |
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Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa.
Prostaglandins 51(1) , 69-79, (1996) To clarify the effects of leukotriene C4 (LTC4) on human ciliated epithelium, ciliary activity of the ethmoid sinus mucosa was measured photoelectrically in tissue culture. At concentrations ranging from 10(-6)M to 10(-9)M, LTC4 showed minimal effects on the ... |
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Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane.
Prostaglandins Leukot. Essent. Fatty Acids 51(3) , 163-71, (1994) We investigated the effects of ONO-1078, a newly synthesized peptide leukotriene (p-LT antagonist, on the specific binding of radiolabelled [3H]-LTC4, [3H]-LTD4 and [3H]-LTE4 to a human lung crude membrane fraction (HLMF). The binding assay was performed unde... |
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Role of leukotriene C4 in follicle-stimulating hormone (FSH) secretion in female rat pituitary.
Gynecol. Endocrinol. 10(2) , 95-100, (1996) Leukotriene C4, at doses of 0.01 and 0.1 nmol/l added to superfused cells in pulse of 4-min duration, evoked follicle-stimulating hormone (FSH) release up to 12- to 26-fold of basal secretion. Higher and lower concentrations of leukotriene C4 were not able to... |
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Leukotriene modifiers in the treatment of asthma. Look promising across the board of asthma severity.
BMJ 316(7140) , 1257-8, (1998)
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Inhibitory effect of a peptide leukotriene antagonist ONO-1078 on LTD4- and antigen-induced thromboxane B2 production in guinea pig lungs.
Life Sci. 52(12) , PL97-102, (1993) The effect of a peptide leukotriene receptor antagonist ONO-1078 on the production of thromboxane (Tx) B2 induced by leukotriene (LT) D4 and antigen challenge was examined in guinea pig lungs. LTD4 (1-1,000 nM) induced a concentration-dependent production of ... |