Arachidonoyl Serotonin结构式
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常用名 | Arachidonoyl Serotonin | 英文名 | Arachidonoyl serotonin |
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| CAS号 | 187947-37-1 | 分子量 | 462.667 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 680.5±55.0 °C at 760 mmHg | |
| 分子式 | C30H42N2O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 365.3±31.5 °C |
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Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels.
Basic Clin Pharmacol Toxicol. 115(4) , 330-4, (2014) Selective blockade of anandamide hydrolysis, through the inhibition of the FAAH enzyme, has anticonvulsant effects, which are mediated by CB1 receptors. Anandamide, however, also activates TRPV1 channels, generally with an opposite outcome on neuronal modulat... |
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The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.
Pharmacol. Res. 61 , 537-46, (2010) Given that the pharmacological or genetic inactivation of fatty acid amide hydrolase (FAAH) counteracts pain and inflammation, and on the basis of the established involvement of transient receptor potential vanilloid type-1 (TRPV1) channels in inflammatory pa... |
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The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats de Novellis, V., et al.
Mol. Pain 17 , 7, (2011)
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Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats.
Pharmacol. Res. 61 , 321-8, (2010) The endocannabinoids anandamide and 2-arachidonoylglycerol, and the anandamide-congener, palmitoylethanolamide, are all substrates for the enzyme fatty acid amide hydrolase, and are endowed with anti-inflammatory actions exerted via cannabinoid receptors or, ... |