酯酶 来源于猪肝脏结构式
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常用名 | 酯酶 来源于猪肝脏 | 英文名 | Carboxylesterase |
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| CAS号 | 9016-18-6 | 分子量 | 367.481 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 566.7±20.0 °C at 760 mmHg | |
| 分子式 | C23H29NO3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 296.5±21.8 °C |
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Pathway Pattern-based prediction of active drug components and gene targets from H1N1 influenza's treatment with maxingshigan-yinqiaosan formula.
Mol. Biosyst. 9(3) , 375-85, (2013) Traditional Chinese Medicine (TCM) remedies are composed of different chemical compounds. To understand the underlying pharmacological basis, we need to explore the active components, which function systematically against multiple gene targets to exert effica... |
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Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity.
Biochem. Biophys. Res. Commun. 434(3) , 534-40, (2013) The alteration of triglyceride (TG) metabolism in vascular smooth muscle cells (SMC) is likely to be correlated with certain phenotype, though this has not been elucidated. Adipose triglyceride lipase (ATGL) exerts major TG catalytic activity in both adipotic... |
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Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.
Stem Cells Transl. Med. 2(12) , 983-92, (2013) CPT-11 (irinotecan) has been investigated as a treatment for malignant brain tumors. However, limitations of CPT-11 therapy include low levels of the drug entering brain tumor sites and systemic toxicities associated with higher doses. Neural stem cells (NSCs... |
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Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1.
Drug Metab. Dispos. 41(11) , 1888-95, (2013) Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor blocker (ARB). We recently identified carboxymethylenebutenolidase homolog (CMBL) as the responsible enzyme for OM bioactivation in humans. In the present study, we compared the bioact... |
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Alteration of the expression of pesticide-metabolizing enzymes in pregnant mice: potential role in the increased vulnerability of the developing brain.
Drug Metab. Dispos. 41(2) , 326-31, (2013) Studies on therapeutic drug disposition in humans have shown significant alterations as the result of pregnancy. However, it is not known whether pesticide metabolic capacity changes throughout pregnancy, which could affect exposure of the developing brain. W... |
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Molecular characterization of two carboxylesterase genes of the citrus red mite, Panonychus citri (Acari: Tetranychidae).
Arch. Insect Biochem. Physiol. 82(4) , 213-26, (2013) The citrus red mite, Panonychus citri, is known for its ability to rapidly evolve resistance to insecticides/acaricides and to adapt to hosts that produce toxins. To get better insight into the detoxification mechanism of P. citri, two carboxylesterase (CarE)... |
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Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors.
Chem. Biol. Interact. 203(1) , 226-30, (2013) Carboxylesterases (CEs) are ubiquitously expressed proteins that are responsible for the detoxification of xenobiotics. They tend to be expressed in tissues likely to be exposed to such agents (e.g., lung and gut epithelia, liver) and can hydrolyze numerous a... |
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Responses of B-esterase enzymes in oysters (Crassostrea gigas) transplanted to pesticide contaminated bays form the Ebro Delta (NE, Spain).
Mar. Pollut. Bull. 66(1-2) , 135-42, (2013) Marine bivalves such as oysters are widely used as bioindicators to monitor marine coastal pollution. This study aimed to use B-esterase activity responses in oysters (Crassostrea gigas) cultured in Ebro Delta bays to monitor environmental effects of pesticid... |
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Injection of phosphatidylcholine and deoxycholic acid regulates gene expression of lipolysis-related factors, pro-inflammatory cytokines, and hormones on mouse fat tissue.
Food Chem. Toxicol. 60 , 263-8, (2013) Injection of phosphatidylcholine (PC) and deoxycholic acid (DA) preparation is widely used as an alternative to liposuction for the reduction of subcutaneous fat. Nevertheless, its physiological effects and mechanism of action are not yet fully understood. In... |
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Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid.
Diabetes 63(1) , 259-69, (2014) Carboxyl-ester lipase (CEL) maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes and pancreatic exocrine dysfunction due to mutations in the CEL gene encoding CEL. The pathogenic mechanism for diabetes development is unknown. Since CEL ... |