葡萄糖激酶 来源于嗜热脂肪芽胞杆菌
葡萄糖激酶 来源于嗜热脂肪芽胞杆菌结构式
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常用名 | 葡萄糖激酶 来源于嗜热脂肪芽胞杆菌 | 英文名 | Glucokinase |
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| CAS号 | 9001-36-9 | 分子量 | 226.232 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 656.2±55.0 °C at 760 mmHg | |
| 分子式 | C9H14N4O3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 350.7±31.5 °C |
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet. 36 , 40-5, (2004) As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique... |
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res. 14 , 2121-7, (2004) The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a r... |
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F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck.
Toxicol. Lett. 228(3) , 192-9, (2014) BPA, a common environmental endocrine disruptor, has been reported to induce epigenetic changes and disrupt glucose homeostasis in F1 offspring through maternal exposure. However, no studies have examined whether maternal BPA exposure can exert multigeneratio... |
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Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence.
Biochem. J. 459(3) , 551-64, (2014) Hepatic glucose phosphorylation by GK (glucokinase) is regulated by GKRP (GK regulatory protein). GKRP forms a cytosolic complex with GK followed by nuclear import and storage, leading to inhibition of GK activity. This process is initiated by low glucose, bu... |
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Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding.
Am. J. Physiol. Endocrinol. Metab. 307(2) , E151-60, (2014) In dogs consuming a high-fat and -fructose diet (52 and 17% of total energy, respectively) for 4 wk, hepatic glucose uptake (HGU) in response to hyperinsulinemia, hyperglycemia, and portal glucose delivery is markedly blunted with reduction in glucokinase (GK... |
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Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 306(7) , R447-56, (2014) Neurons in the supraoptic nuclei (SON) produce oxytocin and vasopressin and express insulin receptors (InsR) and glucokinase. Since oxytocin is an anorexigenic agent and glucokinase and InsR are hallmarks of cells that function as glucose and/or metabolic sen... |
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Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice.
Indian J. Exp. Biol. 52(7) , 683-91, (2014) Ursolic acid (UA) is a pentacyclic triterpenoid compound that naturally occurs in fruits, leaves and flowers of medicinal herbs. This study investigated the dose-response efficacy of UA (0.01 and 0.05%) on glucose metabolism, the polyol pathway and dyslipidem... |
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Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase.
PLoS Biol. 10(12) , e1001452, (2012) Glucokinase (GCK) catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including maturity-onset diabetes of the young typ... |
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Hepatic glucose sensing and integrative pathways in the liver.
Cell. Mol. Life Sci. 71(8) , 1453-67, (2014) The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic glycemia. Here we review the recent literature on its components and metabolic actions. Glu... |
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[Recombinant Escherichia coli strains deficient in mixed acid fermentation pathways and capable of rapid aerobic growth on glucose with a reduced Crabtree effect].
Prikl. Biokhim. Mikrobiol. 49(2) , 136-43, (2013) In this study, we constructed and characterized Escherichia coli strains deficient for mixed acid fermentation pathways, which are capable of rapid aerobic growth on glucose without pronounced bacterial Crabtree effect. The main pathways of production of acet... |