羟丙基纤维素

J. Pharm. Sci. 101(8) , 2941-51, (2012)

Living organisms secrete minerals composed of peptides and proteins, resulting in "mesocrystals" of three-dimensional-assembled composite structures. Recently, this biomimetic polymer-directed crystallization technique has been widely applied to inorganic mat...

Drug Dev. Ind. Pharm. 39(2) , 290-8, (2013)

The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecular weight grades of hydroxypropylcellulose matrices produc...

Chem. Pharm. Bull. 60(11) , 1468-73, (2012)

In this study, amorphous solid dispersions containing dutasteride and various excipients, manufactured by spray-drying processes, were characterized to determine the effects on their ability to form supersaturated solutions and to identify the effects of supe...

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 101 , 67-73, (2013)

The formation constant of triiodide ions from iodine-iodide equilibrium in aqueous-organic solvent or polymer mixed media have been determined spectrophotometrically at three different temperatures 20, 30 and 40°C. The organic solvents chosen for the study ar...

AAPS PharmSciTech 14(1) , 19-28, (2013)

Solid-state NMR spectroscopy (SSNMR), coupled with powder X-ray diffraction (PXRD), was used to identify the physical forms of gabapentin in samples prepared by recrystallization, spray drying, dehydration, and milling. Four different crystalline forms of gab...

Int. J. Pharm. 446(1-2) , 211-8, (2013)

Compression coating, which presents some advantages like short manufacturing process and non-solvent residue over liquid coating, has been introduced to the oral administration systems for decades. The purpose of this study was to design a zero-order release ...

AAPS PharmSciTech 13(4) , 1158-69, (2012)

The objective of this research work was to evaluate Klucel™ hydroxypropylcellulose (HPC) EF and ELF polymers, for solubility enhancement as well as to address some of the disadvantages associated with solid dispersions. Ketoprofen (KPR), a Biopharmaceutics Cl...

J. Colloid. Interface Sci. 381(1) , 198-201, (2012)

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Chem. Pharm. Bull. 60(11) , 1380-6, (2012)

We evaluated models for predicting spray mist diameter suitable for scaling-up the fluidized bed granulation process. By precise selection of experimental conditions, we were able to identify a suitable prediction model that considers changes in binder soluti...

Drug Dev. Ind. Pharm. 39(9) , 1439-46, (2013)

Hydralazine hydrochloride is an antihypertensive used alone or in combination with isosorbide nitrate for the treatment of congestive heart failure. Since control of blood pressure should be continuous, sustained release delivery of this drug is considered th...