异可利定
异可利定结构式
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常用名 | 异可利定 | 英文名 | thyroglobulin, human |
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| CAS号 | 9010-34-8 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | N/A | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Amyloid-like fibril formation by polyQ proteins: a critical balance between the polyQ length and the constraints imposed by the host protein.
PLoS ONE 7 , e31253, (2012) Nine neurodegenerative disorders, called polyglutamine (polyQ) diseases, are characterized by the formation of intranuclear amyloid-like aggregates by nine proteins containing a polyQ tract above a threshold length. These insoluble aggregates and/or some of t... |
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The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis.
J. Immunol. 193(1) , 96-101, (2014) Enhanced iodide ingestion is known to accelerate the incidence and severity of spontaneous autoimmune thyroiditis [iodide-accelerated spontaneous autoimmune thyroiditis (ISAT)] in NOD.H2(h4) mice. CD4+ cells are required for the development and maintenance of... |
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Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008.
Sci. Total Environ. 445-446 , 299-305, (2013) Triclosan and parabens are broad spectrum antimicrobials used in a range of consumer products. In vitro and animal studies have suggested the potential for these compounds to disrupt thyroid function, though studies in humans have been limited. The objective ... |
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Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin.
J. Clin. Endocrinol. Metab. 98(11) , E1768-74, (2013) The mechanisms linking thyroid autoimmunity and iodine use in humans are unknown.Our aim was to correlate iodine intake, thyroid autoimmunity, and recognition of thyroglobulin (Tg) epitopes after implementation of iodine prophylaxis.The general community livi... |
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Hormonogenic donor Tyr2522 of bovine thyroglobulin. Insight into preferential T3 formation at thyroglobulin carboxyl terminus at low iodination level.
Biochem. Biophys. Res. Commun. 450(1) , 488-93, (2014) A tryptic fragment (b5TR,NR), encompassing residues 2515-2750, was isolated from a low-iodine (0.26% by mass) bovine thyroglobulin, by limited proteolysis with trypsin and preparative, continuous-elution SDS-PAGE. The fragment was digested with Asp-N endoprot... |
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Preparation of thyroid follicular cells for mRNA quantification after fluorescence-activated cell sorting.
Scand. J. Clin. Lab. Invest. 73(3) , 245-52, (2013) We established a novel method to analyze cells collected by fluorescence-activated cell sorting (FACS) named mRNA quantification after FACS (FACS-mQ) in which cells are labeled with a fluorescence dye in a manner that minimizes RNA degradation, and then cells... |
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A windowless peek into the brain.
Nature Methods 11(10) , 989, (2014)
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Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis.
J. Immunol. 191(10) , 4940-9, (2013) NOD.H-2h4 mice given NaI in their drinking water develop iodine-accelerated spontaneous autoimmune thyroiditis (ISAT) with chronic inflammation of the thyroid by T and B cells and production of anti-mouse thyroglobulin (MTg) autoantibody. CD28(-/-) NOD.H-2h4 ... |
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Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.
Biochem. Pharmacol. 49 , 1236-47, (2010) Usher syndrome is the major cause of deaf/blindness in the world. It is a genetic heterogeneous disorder, with nine genes already identified as causative for the disease. We noted expression of all known Usher proteins in bovine tracheal epithelial cells and ... |
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Identification of pathogenic T cell epitopes near cathepsin cleavage sites in thyroglobulin.
J. Immunol. 190(4) , 1466-71, (2013) Experimental autoimmune thyroiditis, induced in mice after challenge with thyroglobulin (Tg), is known to be under the genetic control of the H2A(k) locus. Because cathepsins are known to influence proteolytic processing of Tg in vivo, we examined in this stu... |