转移核糖核酸结构式
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常用名 | 转移核糖核酸 | 英文名 | Transfer ribonucleic acids |
|---|---|---|---|---|
| CAS号 | 9014-25-9 | 分子量 | 322.401 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 557.8±50.0 °C at 760 mmHg | |
| 分子式 | C20H22N2O2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 291.1±30.1 °C |
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High-resolution genomic analysis of human mitochondrial RNA sequence variation.
Science 344(6182) , 413-5, (2014) Mutations in the mitochondrial genome are associated with multiple diseases and biological processes; however, little is known about the extent of sequence variation in the mitochondrial transcriptome. By ultra-deeply sequencing mitochondrial RNA (>6000×) fro... |
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Full implementation of the genetic code by tryptophanyl-tRNA synthetase requires intermodular coupling.
J. Biol. Chem. 288(48) , 34736-45, (2013) Tryptophanyl-tRNA Synthetase (TrpRS) Urzyme (fragments A and C), a 130-residue construct containing only secondary structures positioning the HIGH and KMSKS active site signatures and the specificity helix, accelerates tRNA(Trp) aminoacylation with ∼10-fold s... |
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A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines.
Biochemistry 52(24) , 4274-83, (2013) A large number of bioactive natural products containing a 2,5-diketopiperazine (DKP) moiety have been isolated from various microbial sources. Especially tryptophan-containing cyclic dipeptides (CDPs) show great structural and functional diversity, while litt... |
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Recoded organisms engineered to depend on synthetic amino acids.
Nature 518(7537) , 89-93, (2015) Genetically modified organisms (GMOs) are increasingly used in research and industrial systems to produce high-value pharmaceuticals, fuels and chemicals. Genetic isolation and intrinsic biocontainment would provide essential biosafety measures to secure thes... |
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Pyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion tool.
Biochim. Biophys. Acta 1844(6) , 1059-70, (2014) The genetic incorporation of the 22nd proteinogenic amino acid, pyrrolysine (Pyl) at amber codon is achieved by the action of pyrrolysyl-tRNA synthetase (PylRS) together with its cognate tRNA(Pyl). Unlike most aminoacyl-tRNA synthetases, PylRS displays high s... |
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The pre-mRNA retention and splicing complex controls tRNA maturation by promoting TAN1 expression.
Nucleic Acids Res. 41(11) , 5669-78, (2013) The conserved pre-mRNA retention and splicing (RES) complex, which in yeast consists of Bud13p, Snu17p and Pml1p, is thought to promote nuclear retention of unspliced pre-mRNAs and enhance splicing of a subset of transcripts. Here, we find that the absence of... |
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Transcriptome-wide mapping of 5-methylcytidine RNA modifications in bacteria, archaea, and yeast reveals m5C within archaeal mRNAs.
PLoS Genet. 9(6) , e1003602, (2013) The presence of 5-methylcytidine (m(5)C) in tRNA and rRNA molecules of a wide variety of organisms was first observed more than 40 years ago. However, detection of this modification was limited to specific, abundant, RNA species, due to the usage of low-throu... |
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Fructose bisphosphate aldolase is involved in the control of RNA polymerase III-directed transcription
Biochim. Biophys. Acta 1843(6) , 1103-10, (2014) Yeast Fba1 (fructose 1,6-bisphosphate aldolase) is a glycolytic enzyme essential for viability. The overproduction of Fba1 enables overcoming of a severe growth defect caused by a missense mutation rpc128-1007 in a gene encoding the C128 protein, the second l... |
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Early S-phase cell hypersensitivity to heat stress.
Cell Cycle 15 , 337-44, (2016) Heat stress is one of the best-studied exogenous stress factors; however little is known about its delayed effects. Recently, we have shown that heat stress induces cellular senescence-like G2 arrest exclusively in early S-phase cells. The mechanism of this a... |
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Chasing protons: how isothermal titration calorimetry, mutagenesis, and pKa calculations trace the locus of charge in ligand binding to a tRNA-binding enzyme.
J. Med. Chem. 57(13) , 5554-65, (2014) Drug molecules should remain uncharged while traveling through the body and crossing membranes and should only adopt charged state upon protein binding, particularly if charge-assisted interactions can be established in deeply buried binding pockets. Such str... |