肾上腺髓质素(1-52)(人类),三氟乙酸盐结构式
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常用名 | 肾上腺髓质素(1-52)(人类),三氟乙酸盐 | 英文名 | Adrenomedullin (human) |
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| CAS号 | 148498-78-6 | 分子量 | 6028.82 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C264H406N80O77S3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway.
Exp. Biol. Med. (Maywood.) 238(10) , 1136-46, (2013) We previously reported that endoplasmic reticulum (ER) stress-mediated apoptosis participated in vascular calcification. Importantly, a novel paracrine/autocrine peptide intermedin1-53 (IMD1-53) in the vasculature inhibited vascular calcification in rats. But... |
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The effect of intermedin on angiotensin II and endothelin-1 induced ventricular myocyte hypertrophy in neonatal rat.
Clin. Lab. 59(5-6) , 589-96, (2013) Intermedin (IMD), a novel peptide related to calcitonin gene-related peptide (CGRP) and adrenomedullin (ADM), may have localized actions as a modulator of cardiac function. The aim of the study is to explore the effect of IMD on angiotensin II (Ang II) and en... |
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Effects of intermedin1-53 on myocardial fibrosis.
Acta Biochim. Biophys. Sin. (Shanghai) 45(2) , 141-8, (2013) Intermedin (IMD) is a member of the calcitonin/calcitonin gene-related peptide (CGRP) family and has similar or more potent cardiovascular actions than adrenomedullin (ADM) and any other CGRP. The aim of the present work is to study the effects of IMD1-53 on ... |
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Elevated expression of adrenomedullin is correlated with prognosis and disease severity in osteosarcoma.
Med. Oncol. 30(1) , 347, (2013) The treatment for osteosarcoma is a formidable challenge. Currently, treatment is not sufficiently effective, and new therapeutic targets are urgently needed. The aim of this study is to determine the expression of adrenomedullin (ADM) in human osteosarcoma t... |
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Crosstalk-induced loss of miR-126 promotes angiogenesis.
Oncogene 33(28) , 3634-5, (2014) A molecular environment that promotes vascularization around human carcinomas can materialise rapidly, and has been termed the angiogenic switch. Turning this switch toward a proangiogenic state involves an altered interplay between tumor cells and multiple c... |
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New drug for treatment of insulin-resistant complication?
Acta Physiol. (Oxf.) 207(3) , 432-3, (2013)
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Do we now have a 'couch potato' blood test?
Respiration 85(3) , 193-4, (2013)
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Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis.
Circulation 127(7) , 842-53, (2013) Revealing the mechanisms underlying the functional integrity of the vascular system could make available novel therapeutic approaches. We previously showed that knocking out the widely expressed peptide adrenomedullin (AM) or receptor activity-modifying prote... |
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Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine.
Am. J. Physiol. Gastrointest. Liver Physiol. 304(4) , G428-36, (2013) The functional roles of transient receptor potential (TRP) channels in the gastrointestinal tract have garnered considerable attention in recent years. We previously reported that daikenchuto (TU-100), a traditional Japanese herbal medicine, increased intesti... |
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Blood biomarkers for personalized treatment and patient management decisions in community-acquired pneumonia.
Curr. Opin. Infect. Dis. 26(2) , 159-67, (2013) In patients with community-acquired pneumonia (CAP), blood biomarkers can help to substantially improve individual decisions involving initiation, (de-)intensification, and cessation of antibiotics, and initial risk stratification, site-of-care assignment (ou... |