磺胺醋酰
磺胺醋酰结构式
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常用名 | 磺胺醋酰 | 英文名 | sulfacetamide |
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| CAS号 | 144-80-9 | 分子量 | 214.242 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C8H10N2O3S | 熔点 | 182-184 °C | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Simultaneous determination of sulfonamides and metabolites in manure samples by one-step ultrasound/microwave-assisted solid-liquid-solid dispersive extraction and liquid chromatography-mass spectrometry.
Anal. Bioanal. Chem 407(13) , 3545-54, (2015) An in-line matrix cleanup method was used for the simultaneous extraction of 15 sulfonamides and two metabolites from manure samples. The ultrasound/microwave-assisted extraction (UMAE) combined with solid-liquid-solid dispersive extraction (SLSDE) procedure ... |
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Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang.
Environ. Sci. Pollut. Res. Int. 22(3) , 1670-8, (2015) This study investigated the residues of four sulfonamides, four quinolones, and four tetracyclines in surface water as well as surficial sediment samples, of Bosten Lake, in Xinjiang, China. The results showed the presence of 10 out of the 12 selected antibio... |
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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |
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Redesign of MST enzymes to target lyase activity instead promotes mutase and dehydratase activities.
Arch. Biochem. Biophys. 539(1) , 70-80, (2013) The isochorismate and salicylate synthases are members of the MST family of enzymes. The isochorismate synthases establish an equilibrium for the conversion chorismate to isochorismate and the reverse reaction. The salicylate synthases convert chorismate to s... |
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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
J. Med. Chem. 50 , 742-8, (2007) The development of in silico and in vitro tools to estimate or predict the passive human skin permeation and distribution of new chemical entities, useful in dermal drug delivery, in absorption studies of toxic compounds, and in the cosmetics industry, is pre... |
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QSAR-based solubility model for drug-like compounds.
Bioorg. Med. Chem. 18 , 7078-84, (2010) Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a set of relevant parameters for establishing a drug-like chemi... |
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Passive sampling: A cost-effective method for understanding antibiotic fate, behaviour and impact.
Environ. Int. 85 , 284-91, (2015) The occurrence of antibiotics in the environment has raised much concern in recent years. Understanding their release, fate and behaviour in the environment is vital to assess potential risks. In this study, a novel passive water sampler - diffusion gradients... |
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Characterization of the magnesium chelatase from Thermosynechococcus elongatus.
Biochem. J. 457(1) , 163-70, (2014) The first committed step in chlorophyll biosynthesis is catalysed by magnesium chelatase (E.C. 6.6.1.1), which uses the free energy of ATP hydrolysis to insert an Mg(2+) ion into the ring of protoporphyrin IX. We have characterized magnesium chelatase from th... |
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Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters.
Environ. Sci. Pollut. Res. Int. 22 , 16857-67, (2015) An optimized solid-phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-MS/MS) method was developed for the effective analysis of 35 antibiotics including sulfonamides (SAs), quinolones (QLs), tet... |