5-乙酰氨基-6-氨基-3-甲基尿嘧啶(AAMU)
5-乙酰氨基-6-氨基-3-甲基尿嘧啶(AAMU)结构式
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常用名 | 5-乙酰氨基-6-氨基-3-甲基尿嘧啶(AAMU) | 英文名 | N-(6-amino-3-methyl-2,4-dioxo-1H-pyrimidin-5-yl)acetamide |
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| CAS号 | 19893-78-8 | 分子量 | 198.17900 | |
| 密度 | 1.45g/cm3 | 沸点 | N/A | |
| 分子式 | C7H10N4O3 | 熔点 | ≥305ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Caffeine as a metabolic probe: validation of its use for acetylator phenotyping.
Clin. Pharmacol. Ther. 49(6) , 648-57, (1991) The use of two caffeine metabolite ratios for acetylator phenotyping was validated by demonstrating concordance with two sulfamethazine tests in 178 unrelated healthy subjects. The caffeine metabolites used for this purpose were 5-acetylamino-6-amino-3-methyl... |
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An alternative test for acetylator phenotyping with caffeine.
Clin. Pharmacol. Ther. 42(5) , 509-13, (1987) Previously published methods allow the determination of the genetically controlled acetylator status using caffeine as a test drug, based on the urinary excretion of a ring-opened metabolite of caffeine, an acetylated uracil (5-acetylamino-6-formylamino-3-met... |
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Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.
J. Chromatogr. B. Biomed. Sci. Appl. 755(1-2) , 73-84, (2001) Urinary metabolic ratios of caffeine are used in humans to assess the enzymatic activities of cytochrome P450 isoenzyme 1A2 (CYP1A2), xanthine oxidase (XO) and for phenotyping individuals for the bimodal N-acetyltransferase 2 (NAT2), all of them involved in t... |
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A competitive enzyme linked immunosorbent assay for the determination of N-acetyltransferase (NAT2) phenotypes.
J. Pharm. Biomed. Anal. 13(9) , 1079-86, (1995) The ratio of 5-acetylamino-6-amino-3-methyluracil (AAMU) to 1-methylxanthine (1X) in urine samples after caffeine ingestion can be used to indicate human N-acetyltransferase (NAT2) phenotypes. In previous studies, this ratio has been determined by LC or capil... |
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Human N-acetylation genotype determination with urinary caffeine metabolites.
Clin. Pharmacol. Ther. 47(4) , 470-7, (1990) The human acetylation genotype was determined by measuring urinary caffeine metabolites by use of a modification of a previously published HPLC method. The problem of separation of 7-methylxanthine (7X) from 1-methyluric acid (IU) in urine extracts was achiev... |
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Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?
Eur. J. Clin. Pharmacol. 65(4) , 411-7, (2009) Individual activities of N-acetyltransferase 2 (NAT2) and of xanthine oxidase (XO) can be assessed using ratios of urinary caffeine metabolites. We investigated how ratios changed over time and which urine collection interval would be the best for NAT2 and XO... |
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N-acetylator variability in Down's syndrome: characterization with caffeine.
Clin. Pharmacol. Ther. 46(3) , 359-66, (1989) Little is known regarding the biotransformation of drugs in Down's syndrome. In particular, there are no published studies that examine metabolic pathways such as N-acetylation, which can exhibit genetically-determined variability. The objective of the presen... |
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Acetylator phenotype in patients with p-phenylenediamine allergy.
Dermatology 195(1) , 43-5, (1997) p-Phenylenediamine (PPD) has been widely distributed as hair dye ingredient and may be responsible for contact dermatitis. Since not all the subjects exposed to PPD react to the substance, we tested a possible predisposing factor of cutaneous drug metabolism.... |
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Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay.
Clin. Chim. Acta 376(1-2) , 240-3, (2007) The utility of typing single nucleotide polymorphisms (SNPs) for the determination of the N-acetyltransferase 2 (NAT2) acetylation status is a matter of debate.Evaluation of the concordance between deduced genotype results of seven human NAT2 SNPs generated b... |
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Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.
Eur. J. Clin. Pharmacol. 60(1) , 17-21, (2004) The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. We tested whether these standardization measures were still ... |