血红蛋白A2,经亚铁稳定 人

East. Mediterr. Health J. 20(11) , 726-31, (2014)

This study investigated the prevalence of iron-deficiency anaemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency and β-thalassaemia trait among Arab migrating nomad children in southern Islamic Republic of Iran. Blood samples were analysed from 134 scho...

Clin. Chim. Acta 413(19-20) , 1705-7, (2012)

An increased HbA2 level is the hallmark for identification of β thalassemia carriers. However, in some carriers the level of HbA2 is not typically elevated creating difficulties in making a diagnosis.We describe a family having an affected child referred to u...

Hemoglobin 36(5) , 511-5, (2012)

We describe two frameshift mutations associated with an α-thalassemia (α-thal) phenotype, identified in three unrelated individuals investigated for persistent microcytosis. The first mutation, HBA2:c.131delT, is located in codon 43, and the second, HBA2:c.14...

Pediatr. Hematol. Oncol. 29(5) , 472-8, (2012)

Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. Howeve...

Hemoglobin 36(4) , 381-7, (2012)

The α-thalassemia-1 (α-thal-1) Southeast Asian (- -(SEA)) type deletion, β-thalassemia (β-thal) and Hb E [β26(B8)Glu→Lys, GAG>AAG] are the most common genetic disorders in Southeast Asian populations. Mean corpuscular volume (MCV) <80.0 fL with normal hemoglo...

Hemoglobin 37(1) , 80-4, (2013)

We report two new variants of the δ-globin gene: Hb A(2)-Saint-Etienne [δ14(A11)Leu→Pro] and Hb A(2)-Marseille [δ22(B4)Ala→Lys]. The first variant has a low rate of expression, the second results from a double nucleotide mutation on the same codon.

J. Matern. Fetal. Neonatal. Med. 26(5) , 445-8, (2013)

This research, conducted on 1495 couples in preconceptional period, demonstrates how the study of globular resistance of erythrocytes (GRO) is not a first choice test and not useful as other more accurate tests to identify subjects with β-thalassemia trait. I...

J. Pak. Med. Assoc. 62(12) , 1314-7, (2012)

To screen immediate family members of thalassaemia patients for carrier identification and counselling.The cross-sectional study was conducted at an urban thalassaemia treatment and prevention centre in Karachi, Pakistan, from January to December 2008, and in...

Pediatr. Hematol. Oncol. 30(2) , 113-5, (2013)

Hemoglobin 37(1) , 85-93, (2013)

Although δ-globin gene (HBD MIM#142000) mutations have no immediate physical consequence, it can interfere with the diagnosis of β-thalassemia (β-thal), which can be severe. In the present study, of 40,863 samples referred for thalassemia trait screening, 167...