氯化镁
氯化镁结构式
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常用名 | 氯化镁 | 英文名 | Magnesium choride |
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| CAS号 | 7786-30-3 | 分子量 | 95.21 | |
| 密度 | 2.32 g/mL at 25 °C(lit.) | 沸点 | 1412°C | |
| 分子式 | Cl2Mg | 熔点 | 714 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Functional consequence of the MET-T1010I polymorphism in breast cancer.
Oncotarget 6(5) , 2604-14, (2015) Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an unc... |
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Aptamer-based polyvalent ligands for regulated cell attachment on the hydrogel surface.
Biomacromolecules 16(4) , 1382-9, (2015) Natural biomolecules are often used to functionalize materials to achieve desired cell-material interactions. However, their applications can be limited owing to denaturation during the material functionalization process. Therefore, efforts have been made to ... |
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Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
J. Clin. Invest. 125(2) , 607-20, (2015) Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited nephropathy responsible for 4%-10% of end-stage renal disease cases. Mutations in the genes encoding polycystin-1 (PC1, PKD1) or polycystin-2 (PC2, PKD2) cause ADPKD, and PKD1 mutation... |
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The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.
Drug Des. Devel. Ther. 9 , 1627-52, (2015) Alisertib (ALS) is an investigational potent Aurora A kinase inhibitor currently undergoing clinical trials for the treatment of hematological and non-hematological malignancies. However, its antitumor activity has not been tested in human breast cancer. This... |
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Inhibition of a multiproduct terpene synthase from Medicago truncatula by 3-bromoprenyl diphosphates.
Org. Biomol. Chem. 13(16) , 4776-84, (2015) The multiproduct sesquiterpene synthase MtTPS5 from Medicago truncatula catalyzes the conversion of farnesyl diphosphate (FDP) into a complex mixture of 27 terpenoids. 3-Bromo substrate analogues of geranyl diphosphate (3-BrGDP) and farnesyl diphosphate (3-Br... |
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Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.
Drug Des. Devel. Ther. 9 , 1555-84, (2015) Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays a... |
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Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem. J. 467(2) , 345-52, (2015) Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage types. Whereas some linkages have been studied in detail, other link... |
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Fine mapping and characterization of the L-polymerase-binding domain of the respiratory syncytial virus phosphoprotein.
J. Virol. 89(8) , 4421-33, (2015) The minimum requirement for an active RNA-dependent RNA polymerase of respiratory syncytial virus (RSV) is a complex made of two viral proteins, the polymerase large protein (L) and the phosphoprotein (P). Here we have investigated the domain on P that is res... |
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Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.
Drug Des. Devel. Ther. 9 , 425-64, (2015) Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of ad... |
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Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.
Nat. Commun. 5 , 5419, (2014) The ATP-binding cassette (ABC) transporter associated with antigen processing (TAP) participates in immune surveillance by moving proteasomal products into the endoplasmic reticulum (ER) lumen for major histocompatibility complex class I loading and cell surf... |