L-色氨酸乙酯盐酸盐结构式
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常用名 | L-色氨酸乙酯盐酸盐 | 英文名 | H-Trp-Oet·HCl |
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| CAS号 | 2899-28-7 | 分子量 | 268.739 | |
| 密度 | N/A | 沸点 | 401.2ºC at 760 mmHg | |
| 分子式 | C13H17ClN2O2 | 熔点 | 220-225 °C (dec.) | |
| MSDS | 美版 | 闪点 | 196.4ºC |
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Solvent effects on the fluorescence quenching of tryptophan by amides via electron transfer. Experimental and computational studies.
J. Phys. Chem. B 113 , 2572-2577, (2009) Hybrid quantum mechanical/molecular mechanics (QM-MM) calculations [Callis and Liu, J. Phys. Chem. B 2004, 108, 4248-4259] make a strong case that the large variation in tryptophan (Trp) fluorescence yields in proteins is explained by ring-to-backbone amide e... |
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L-tryptophan ethyl ester dilates small mesenteric arteries by inhibition of voltage-operated calcium channels in smooth muscle.
Br. J. Pharmacol. 166(1) , 232-42, (2012) L-tryptophan (L-W) is a precursor of the vasoconstrictor, 5-HT. However, acute administration of L-W ethyl ester (L-Wee) lowered blood pressure. The mechanism of action is unknown. This study compares the vascular effects of L-W and L-Wee in intact animals, i... |
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[pH dependence of tryptophan ethyl ester hydrolysis].
Biokhimiia 45(5) , 829-34, (1980) The dependence of the rate of spontaneous hydrolysis of tryptophan ethyl ester within a wide range of pH (4,6-10,3) was studied. This dependence was found to differ from other dependences, i.e. within the pH range of 4,6-7,0 the value of the rate constant is ... |
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[pH-dependence of tryptophan ethyl ester hydrolysis by alpha-chymotrypsin].
Biokhimiia 45(4) , 629-35, (1980) The hydrolysis of L-tryptophane ethyl ester catalyzed by alpha-chymotrypsin and the effect of ethyl ster of D-tryptophane on the course of the reaction were studied. A kinetic pattern of a three-step enzymatic reaction based on the assumption that the enzyme ... |
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Facilitating effect of insulin on brain 5-hydroxytryptamine metabolism.
Neuroendocrinology 45(4) , 267-73, (1987) In this study we investigated the effect of insulin on striatal 5-hydroxytryptamine and tryptamine in streptozotocin-diabetic and in normal rats. Streptozotocin-diabetic rats show a reduction in rat striatal tryptophan, 5-hydroxytryptamine, and 5-hydroxyindol... |
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Hydrogen bonding and solvent polarity markers in the uv resonance raman spectrum of tryptophan: application to membrane proteins.
J. Phys. Chem. B 113(44) , 14769-78, (2009) Ultraviolet resonance Raman (UVRR) spectra of tryptophan compounds in various solvents and a model peptide are presented and reveal systematic changes that reflect solvent polarity, hydrogen bond strength, and cation-pi interaction. The commonly utilized UVRR... |
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Separation of tryptophan-derivative enantiomers with iron-free human serum transferrin by capillary zone electrophoresis.
Electrophoresis 16(8) , 1510-8, (1995) Enantiomers can be separated by using human serum transferrin as a chiral phase. With the help of the native protein we were able to separate enantiomers with high efficiency, using a low ionic strength 2-(N-morpholino)ethanesulfonic acid (MES) buffer, pH 6, ... |
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Circumvention of defective neutral amino acid transport in Hartnup disease using tryptophan ethyl ester.
J. Clin. Invest. 84(1) , 200-4, (1989) Tryptophan ethyl ester, a lipid-soluble tryptophan derivative, was used to bypass defective gastrointestinal neutral amino acid transport in a child with Hartnup disease. The child's baseline tryptophan concentrations in serum (20 +/- 6 microM) and cerebrospi... |
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Radiosynthesis of 1-[18F]fluoroethyl-L-tryptophan as a novel potential amino acid PET tracer.
Appl. Radiat. Isot. 70(4) , 676-80, (2012) (18)F labeled natural amino acids have been introduced as promising tumor imaging agents. A novel [(18)F]fluoro amino acid analog 1-[(18)F]fluoroethyl-L-tryptophan (1-[(18)F]FETrp) was designed and synthesized by a two-pot three-step procedure, including the ... |
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Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation.
J. Control. Release 116(3) , 322-9, (2006) The effects of copolymer composition, drug structure and initial drug feed on drug loading of polymeric micelles based on amphiphilic polyphosphazenes were investigated. It was found that the drug loading capacity of micelles based on this type of amphiphilic... |