N-乙酰-L-脯氨酸结构式
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常用名 | N-乙酰-L-脯氨酸 | 英文名 | N-acetyl-L-proline |
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CAS号 | 68-95-1 | 分子量 | 157.17 | |
密度 | 1.3±0.1 g/cm3 | 沸点 | 366.2±35.0 °C at 760 mmHg | |
分子式 | C7H11NO3 | 熔点 | 115-117 °C | |
MSDS | 中文版 美版 | 闪点 | 175.3±25.9 °C |
Quantum mechanical and NMR studies of ring puckering and cis/trans-rotameric interconversion in prolines and hydroxyprolines.
J. Phys. Chem. A 113(40) , 10858-65, (2009) Nuclear magnetic resonance (NMR) and quantum mechanical (QM) studies have been carried out for proline (Pro) containing peptides: N-acetyl-l-proline (AcProOH) and N-acetyl-4-hydroxy-l-proline (AcHypOH). Preliminary results of variable temperature NMR measurem... |
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Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.
J. Med. Chem. 31 , 1148-1160, (1988) Analogues of captopril, enalaprilat, and the phosphinic acid [hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline incorporating 4-substituted proline derivatives have been synthesized and evaluated as inhibitors of angiotensin-converting enzyme (ACE) in vitro ... |
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Synergistic binding of ligands to angiotensin-converting enzyme.
J. Biol. Chem. 263 , 4056-4068, (1988) We have investigated the interaction of ligands in the active site of the angiotensin-converting enzyme from rabbit lung by monitoring the concurrent effects of two inhibitors on enzyme activity. A strong synergism is found in the binding of N-acetyl-L-prolin... |
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Conformational analysis of L-prolines in water.
J. Phys. Chem. B 111 , 14034-14042, (2007) The results of the ring conformational analysis of L-proline, N-acetyl-L-proline, and trans-4-hydroxy-L-proline by NMR combined with calculations using density functional theory (DFT) and molecular dynamics (MD) are reported. Accurate values of 1H-1H J-coupli... |
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Purification and characterization of a novel aminoacylase from Streptomyces mobaraensis.
Biosci. Biotechnol. Biochem. 69 , 1914-1922, (2005) A novel aminoacylase was purified to homogeneity from culture broth of Streptomyces mobaraensis, as evidenced by SDS-polyacrylamide gel electrophoresis (PAGE). The enzyme was a monomer with an approximate molecular mass of 100 kDa. The purified enzyme was inh... |
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Synthesis and evaluation of N-acetylprolinate esters - novel skin penetration enhancers.
Int. J. Pharm. 192(2) , 147-58, (1999) A series of N-acetylproline esters (alkyl side chain length, 5-18) were synthesized and tested for potential skin penetration enhancement activity using modified Franz diffusion cells and hairless mouse skin as the penetration barrier. Benazepril and hydrocor... |
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Structure of N-acetylproline amide in liquid water: experimentally measured and numerically simulated infrared and vibrational circular dichroism spectra.
J. Phys. Chem. B 110(38) , 18834-43, (2006) A few experimental and theoretical studies on the molecular structure of N-acetylproline amide (AP) in D2O solution have been reported recently. However, there is no consensus of the precise structure of AP in D2O because spectroscopically determined structur... |
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Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets.
J. Am. Chem. Soc. 127(7) , 2044-5, (2005) Structure-based design of a bifunctional ligand for two protein pentamers, cholera toxin B pentamer (CTB) and human serum amyloid P component (SAP), leads to multivalent dimerization of CTB and SAP in solution. This multivalent heterodimerization of proteins ... |
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The influence of the peptide bond on the conformation of amino acids: a theoretical and FT-IR matrix-isolation study of N-acetylproline.
Biophys. Chem. 159(2-3) , 247-56, (2011) A combined experimental matrix-isolation FT-IR and theoretical study has been performed to investigate the conformational behavior of N-acetylproline. The conformational landscape of N-acetylproline was explored using successively higher computational methods... |
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Modeling the solvation of peptides. The case of (s)-N-acetylproline amide in liquid water.
J. Phys. Chem. B 112(11) , 3441-50, (2008) The structure and properties of (s)-N-acetylproline amide (NAP) in aqueous solution are studied by exploiting a continuum solvation model. The conformational preference of NAP as a function of the environment is discussed as well as data for a number of chira... |