生物素酰肼
生物素酰肼结构式
|
常用名 | 生物素酰肼 | 英文名 | Biotin Hydrazide |
|---|---|---|---|---|
| CAS号 | 66640-86-6 | 分子量 | 258.341 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 633.1±40.0 °C at 760 mmHg | |
| 分子式 | C10H18N4O2S | 熔点 | 245-247 °C | |
| MSDS | 中文版 美版 | 闪点 | 336.7±27.3 °C |
|
Sensitive chemiluminescent imaging for chemoselective analysis of glycan expression on living cells using a multifunctional nanoprobe.
Anal. Chem. 84(3) , 1452-8, (2012) A novel sensitive chemiluminescent (CL) imaging method was developed for in situ monitoring of cell surface glycan expression through chemoselective labeling of carbohydrate motifs and then binding to a multifunctional nanoprobe. The nanoprobe was fabricated ... |
|
|
Determining the effects of antioxidants on oxidative stress induced carbonylation of proteins.
Anal. Chem. 83(24) , 9328-36, (2011) There is potential that the pathological effects of oxidative stress (OS) associated diseases such as diabetes could be ameliorated with antioxidants, but this will require a clearer understanding of the pathway(s) by which proteins are damaged by OS. This st... |
|
|
Qualitative and quantitative evaluation of derivatization reagents for different types of protein-bound carbonyl groups.
Analyst 138(17) , 5081-8, (2013) Mass spectrometry (MS) of 'carbonylated proteins' often involves derivatization of reactive carbonyl groups to facilitate their enrichment, identification and quantification. Among the many reported reagents, 2,4-dinitrophenylhydrazine (DNPH), biotin hydrazid... |
|
|
Substrate profiling of protein tyrosine phosphatase PTP1B by screening a combinatorial peptide library.
J. Am. Chem. Soc. 129(17) , 5366-7, (2007)
|
|
|
Comparing the efficiencies of hydrazide labels in the study of protein carbonylation in human serum albumin.
Anal. Bioanal. Chem 404(5) , 1399-411, (2012) In this work, we establish a methodology for comparing the efficiencies of different hydrazide labels for detecting protein carbonyls. We have chosen acrolein-modified human serum albumin as a model. This system provides a convenient means of reproducibly gen... |
|
|
Engineering novel cell surface receptors for virus-mediated gene transfer.
J. Biol. Chem. 274(31) , 21878-84, (1999) The absence of viral receptors is a major barrier to efficient gene transfer in many cells. To overcome this barrier, we developed an artificial receptor based on expression of a novel sugar. We fed cells an unnatural monosaccharide, a modified mannosamine th... |
|
|
Kinetic parameters for small-molecule drug delivery by covalent cell surface targeting.
Biochim. Biophys. Acta 1568(2) , 147-54, (2001) Human cells incubated with N-levulinoylmannosamine (ManLev) process this unnatural metabolic precursor into N-levulinoyl sialic acid (SiaLev), which is incorporated into cell surface glycoconjugates. A key feature of SiaLev is the presence of a ketone group t... |
|
|
Independently-addressable micron-sized biosensor elements.
Biosens. Bioelectron. 18(10) , 1299-307, (2003) With the continuing development of micro-total analysis systems and sensitive biosensing technologies, it is often desirable to immobilize biomolecules onto a surface in a small well-defined area. A novel method was developed to electrochemically attach DNA p... |
|
|
Protein-RNA cross-linking in the ribosomes of yeast under oxidative stress.
J. Proteome Res. 5(12) , 3249-59, (2006) Living systems have efficient degradative pathways for dealing with the fact that reactive oxygen species (ROS) derived from cellular metabolism and the environment oxidatively damage proteins and DNA. But aggregation and cross-linking can occur as well, lead... |
|
|
Fast in vitro translation system immobilized on a surface via specific biotinylation of the ribosome.
Biol. Chem. 389(9) , 1239-49, (2008) The ribosome is the macromolecular machine responsible for translating the genetic code into polypeptide chains. Despite impressive structural and kinetic studies of the translation process, a number of challenges remain with respect to understanding the dyna... |