乙氧基试卤灵
乙氧基试卤灵结构式
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常用名 | 乙氧基试卤灵 | 英文名 | 7-Ethoxyresorufin |
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| CAS号 | 5725-91-7 | 分子量 | 241.242 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 389.3±42.0 °C at 760 mmHg | |
| 分子式 | C14H11NO3 | 熔点 | 223-225ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 185.9±22.3 °C |
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The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells.
Chem. Biol. Interact. 221 , 70-6, (2014) Licorice is derived from the rhizomes of Glycyrrhiza glabra. It has been used for confectioneries or culinary purposes. The rhizomes contain many flavonoidal compounds that have been shown to be biologically active. In the present study, effect of the licoric... |
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Inhibition of cytochrome P450 1A2-mediated metabolism and production of reactive oxygen species by heme oxygenase-1 in rat liver microsomes.
Drug Metab. Lett. 5(1) , 6-16, (2011) Heme oxygenase-1 (HO-1) is induced in most cell types by many forms of environmental stress and is believed to play a protective role in cells exposed to oxidative stress. Metabolism by cytochromes P450 (P450) is highly inefficient as the oxidation of substra... |
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The aryl hydrocarbon receptor pathway and the response to 3-methylcholanthrene are altered in the liver of adrenalectomized rats.
Drug Metab. Dispos. 39(1) , 83-91, (2011) The aryl hydrocarbon receptor (AHR) is activated by 3-methylcholanthrene (MC), a polycyclic aromatic hydrocarbon, and environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Adrenalectomized (ADX) rats have decreased hepatic AHR protein and l... |
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Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin.
Lung Cancer 71(3) , 298-305, (2011) It is believed that the chemopreventive activity of cruciferous vegetables in the lung and other tissues is exclusively the result of exposure to degradation products of glucosinolates, such as the isothiocyanates, and that the parent glucosinolates make no c... |
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CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey.
Biochem. Pharmacol. 81(3) , 442-50, (2011) Cytochrome P450 (P450 or CYP) 1 family consists of the CYP1A, CYP1B, CYP1C, and CYP1D subfamilies. In the human genome, CYP1A1, CYP1A2, and CYP1B1 are expressed and encode functional enzymes, whereas CYP1D1P (formerly known as CYP1A8P) is present as a pseudog... |
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Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.
Mol. Nutr. Food. Res. 56(3) , 425-34, (2012) The aryl hydrocarbon (Ah) receptor is a ligand-activated transcription factor that is activated by many carcinogens, and its target gene products play a major role in tumour development, so that antagonists of the Ah receptor represent potential chemopreventi... |
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Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.
J. Pharmacol. Exp. Ther. 339(2) , 654-61, (2011) The cynomolgus monkey is widely used as a primate model in preclinical studies because of its evolutionary closeness to humans. Despite their importance in drug metabolism, the content of each cytochrome P450 (P450) enzyme has not been systematically determin... |
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Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices.
Biotechnol. Bioeng. 104(3) , 516-25, (2009) We describe an in situ fluorescence optical detection system to demonstrate real-time and non-invasive detection of reaction products in a microfluidic device while under perfusion within a standard incubator. The detection system is designed to be compact an... |
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Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.
Drug Metab. Dispos. 38(5) , 732-9, (2010) Human cytochrome P450 (P450) enzymes metabolize a variety of endogenous and xenobiotic compounds, including steroids, drugs, and environmental chemicals. In this study, we examine the possibility that bacterial P450 BM3 (CYP102A1) mutants with indole oxidatio... |
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The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor.
Arch. Toxicol. 86(10) , 1505-14, (2012) As the Ah receptor target gene products play a critical role in chemical carcinogenesis, antagonists are considered as potential chemopreventive agents. It is demonstrated in this paper that the isothiocyanates R,S-sulforaphane and erucin are non-competitive ... |