(+/-)-4-羟基普萘洛尔盐酸盐
(+/-)-4-羟基普萘洛尔盐酸盐结构式
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常用名 | (+/-)-4-羟基普萘洛尔盐酸盐 | 英文名 | 4-hydroxy propranolol hcl |
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| CAS号 | 14133-90-5 | 分子量 | 311.804 | |
| 密度 | 1.168g/cm3 | 沸点 | 487.5ºC at 760mmHg | |
| 分子式 | C16H22ClNO3 | 熔点 | 156-158ºC | |
| MSDS | 美版 | 闪点 | 248.6ºC |
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Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization.
J. Chromatogr. B. Biomed. Sci. Appl. 692(1) , 133-40, (1997) A stereoselective reversed-phase HPLC assay to quantify S-(-) and R-(+) enantiomers of propranolol and 4-hydroxypropranolol in human plasma was developed. The method involved liquid-liquid extraction for sample clean-up and employed 2,3,4,6-tetra-O-acetyl-bet... |
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Potential bias and mitigations when using stable isotope labeled parent drug as internal standard for LC–MS/MS quantitation of metabolites
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(31) , 3267-76, (2010) In recent years, increasing emphasis has been placed on quantitative characterization of drug metabolites for better insight into the correlation between metabolite exposure and toxicological observations or pharmacological efficacy. One common strategy for m... |
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Potent antioxidant properties of 4-hydroxyl-propranolol.
J. Pharmacol. Exp. Ther. 308(1) , 85-90, (2004) The antioxidant properties of 4-HO-propranolol (4HOP), a major metabolite of propranolol, were studied and compared with that of propranolol and vitamin E (Trolox). When isolated hepatic microsomal membranes were peroxidized by an iron-catalyzed.OH-generating... |
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Hep G2 cell line as a human model for sulphate conjugation of drugs.
Xenobiotica 22(8) , 973-82, (1992) 1. The objective of this study was to examine the usefulness of the hepatoma cell line Hep G2 as a model for human sulphoconjugation of drugs, in particular stereoselective conjugation. 2. Using the substrates p-nitrophenol and dopamine, we found sulphation a... |
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Involvement of SULT1A3 in elevated sulfation of 4-hydroxypropranolol in Hep G2 cells pretreated with beta-naphthoflavone.
Biochem. Pharmacol. 69(6) , 941-50, (2005) Pretreatment of Hep G2 cells with beta-naphthoflavone (BNF 1-25microM) significantly increased cytosolic sulfation activities of 4-hydroxypropranolol (4-OH-PL) racemate. The profile was similar to those of sulfations towards dopamine and triiodothyronine in t... |
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Immunoaffinity isolation of the sulfate conjugate of 4'-hydroxypropranolol from plasma.
J. Chromatogr. A. 612(2) , 320-5, (1993) Selective extraction of sulfate conjugates of basic drugs from biological matrices has been difficult because of their highly polar nature. Immunoaffinity isolation may be the best solution to this analytical problem. This was tested for a model compound, the... |
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A pharmacokinetic interaction study of avitriptan and propranolol.
Clin. Pharmacol. Ther. 63(3) , 367-78, (1998) To assess whether a clinically significant change in the pharmacokinetics of avitriptan and propranolol is observed in healthy subjects after coadministration of the two drugs.The pharmacokinetics of avitriptan and propranolol were investigated when the two d... |
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The influence of diltiazem versus cimetidine on propranolol metabolism.
J. Clin. Pharmacol. 32(12) , 1099-104, (1992) The present study was undertaken to examine whether the inhibitory effect of diltiazem on the metabolism of propranolol differs from that of cimetidine. Six healthy male volunteers received a single oral dose of 20 mg propranolol with pretreatment with placeb... |
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Comparative study of the oxidation of propranolol enantiomers in hepatic and small intestinal microsomes from cynomolgus and marmoset monkeys.
Chem. Biol. Interact. 183(1) , 67-78, (2010) Oxidative metabolism of propranolol (PL) enantiomers (R-PL and S-PL) to 4-hydroxypropranolol (4-OH-PL), 5-OH-PL and N-deisopropylpropranolol (NDP) was examined in hepatic microsomes from cynomolgus and marmoset monkeys and in small intestinal microsomes from ... |
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Haemodynamic, electrocardiographic, electrophysiologic and pharmacokinetic activity of 4'-hydroxypropranolol in dogs.
J. Vet. Pharmacol. Ther. 19(4) , 259-67, (1996) We determined the haemodynamic, electrocardiographic and electrophysiologic effects, and the pharmacokinetic properties of 4'-hydroxypropranolol (4'-OHP) by conducting three different experiments in dogs. In experiment 1 the plasma concentrations of 4'-OHP (m... |