伊马咪啶
伊马咪啶结构式
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常用名 | 伊马咪啶 | 英文名 | IMAZODAN |
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| CAS号 | 84243-58-3 | 分子量 | 240.26100 | |
| 密度 | 1.34g/cm3 | 沸点 | N/A | |
| 分子式 | C13H12N4O | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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New mechanisms for positive inotropic agents: focus on the discovery and development of imazodan.
Cardiovasc. Drugs Ther. 3(1) , 29-42, (1989) Intense efforts during the last decade to identify a useful positive inotropic agent to replace digitalis for the treatment of congestive heart failure have led to the discovery of several dozen potential substitutes, of which a number are currently undergoin... |
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Determination of 4,5-dihydro-6-[4-(1H-imidazol-1-yl) phenyl]-3(2H)-pyridazinone hydrochloride, a new cardiotonic, in plasma and urine by reversed-phase high-performance liquid chromatography.
J. Chromatogr. A. 336(2) , 446-51, (1984)
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Effect of a new phosphodiesterase type III inhibitor as a coronary vasodilator and positive inotropic agent.
Cardiovasc. Res. 21(8) , 593-600, (1987) Isolated rabbit coronary arteries, aortic strips, and a working rabbit heart preparation were used to assess the positive inotropic and vasodilator effects of a newly developed positive inotropic compound, CI 914. The substance had a relaxing effect on histam... |
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Inotropic and chronotropic profile of MCI-154: comparison with isoproterenol and imazodan in guinea pig cardiac preparations.
J. Cardiovasc. Pharmacol. 16(1) , 59-67, (1990) Although recent studies indicate that MCI-154 exerts novel positive inotropic actions in heart muscle, the chronotropic properties of this new drug remain undefined. The present study compared the inotropic/chronotropic profile of MCI-154 with those of a nons... |
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Effects of CI-914 in congestive heart failure due to coronary artery disease or idiopathic cardiomyopathy.
Am. J. Cardiol. 58(7) , 596-600, (1986) The hemodynamic effects of CI-914, a phosphodiesterase inhibitor, were studied in 12 patients with left ventricular (LV) dysfunction who were undergoing diagnostic cardiac catheterization. CI-914 was infused intravenously at a rate of 0.8 to 7.0 micrograms/kg... |
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[Phosphodiesterase inhibition as a new positive-inotropic principle].
Dtsch. Med. Wochenschr. 111(51-52) , 1971-7, (1986)
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Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro.
Zhongguo Yao Li Xue Bao 14(4) , 347-50, (1993) Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ... |
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Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.
J. Med. Chem. 27(9) , 1099-101, (1984)
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[Effects of imazodan and dazoxiben on cAMP levels and PGI2 production in cultured bovine aortic endothelial cells].
Zhongguo Yao Li Xue Bao 10(5) , 421-4, (1989) We have investigated the effects of imazodan, a potent inhibitor of phosphodiesterase III (PDE III) and dazoxiben, a selective inhibitor of thromboxane synthetase on cAMP levels and PGI2 production in cultured bovine aortic endothelial cells by radioimmunoass... |
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Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex.
Biochemistry 47 , 7485-95, (2008) The interaction of Cardiac Troponin C (cTnC) and Cardiac Troponin I (cTnI) plays a critical role in transmitting the Ca (2+) signal to the other myofilament proteins in the activation of cardiac muscle contraction. As such, the cTnC-cTnI interface is a logica... |