积雪草酸结构式
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常用名 | 积雪草酸 | 英文名 | Asiatic acid |
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| CAS号 | 464-92-6 | 分子量 | 488.699 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 609.4±55.0 °C at 760 mmHg | |
| 分子式 | C30H48O5 | 熔点 | 325-330 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 336.4±28.0 °C |
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Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC-MS method.
J. Ethnopharmacol. 163 , 31-8, (2015) Asiatic acid is one of the main components in the herb Centella asiatica, which is a well-known herbal medicine for its excellent pharmacological effects. To enhance the development potentials of asiatic acid as a chemopreventative agent, there is a great nee... |
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Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.
Int. Immunopharmacol. 24(2) , 232-8, (2015) In the present study, the effect of asiatic acid, a natural triterpenoid compound, on murine experimental colitis induced by dextran sulfate sodium (DSS) and its possible mechanism were examined in vivo and vitro. Oral administration of asiatic acid dose-depe... |
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Effecting skin renewal: a multifaceted approach.
J. Cosmet. Dermatol. 10(2) , 126-30, (2011) The skin undergoes intrinsic aging as a normal course, but exposure to ultraviolet (UV) light results in major cumulative damage that manifests as the typical aged photodamaged skin. UV irradiation produces a sequence of changes within the skin layers startin... |
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Two new oxidation products obtained from the biotransformation of asiatic acid by the fungus Fusarium avenaceum AS 3.4594.
J. Asian Nat. Prod. Res. 14(11) , 1039-45, (2012) Asiatic acid (AA) is a natural triterpenoid possessing anti-inflammatory, anticancer, neuroprotective, and hepatoprotective activities. Structural modification of AA may provide valuable information for further structure-activity relationship analysis. Biotra... |
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Microbial transformation of asiatic acid.
J. Asian Nat. Prod. Res. 15(1) , 15-21, (2013) Asiatic acid (1), a major pentacyclic triterpene of Centella asiatica, was subjected to transformation by Penicillium lilacinum ACCC 31890, Fusarium equiseti CGMCC 3.3658, and Streptomyces griseus CGMCC 4.18 strains. Incubation of asiatic acid with P. lilacin... |
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Contact dermatitis due to Centella asiatica.
Contact Dermatitis 62(1) , 54-5, (2010)
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[Triterpenoids from leaves of Ilex cornuta].
Zhongguo Zhong Yao Za Zhi 34(8) , 999-1001, (2009) To investigate the chemical constituents of Ilex cornuta.The chemical constituents were isolated by column chromatographic methods. And the structures were identified by spectral data.Seven compounds were isolated and identified as follows: 2alpha-hydroxy urs... |
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Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro.
PLoS ONE 7(2) , e31350, (2012) Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) in a rat model of liver fibrosis induced by carbon tetrachloride ... |
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Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats.
Phytomedicine 20(3-4) , 230-6, (2013) Asiatic acid (AA), a triterpenoid derivative of Centella asiatica, has shown significant biological effects of antioxidant and anti-inflammatory activities. Aim of this investigation was to evaluate the antihyperglycemic effect of AA on the activities of hepa... |
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In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.
J. Ethnopharmacol. 130(2) , 275-83, (2010) Centella asiatica (CA) has been widely cultivated as a vegetable or spice in China, Southeast Asia, India, Sri Lanka, Africa, and Oceanic countries and traditionally used for wound healing and maintaining normal blood pressure.The present study was carried ou... |