蔓荆子黄素
蔓荆子黄素结构式
|
常用名 | 蔓荆子黄素 | 英文名 | Vitexicarpin |
|---|---|---|---|---|
| CAS号 | 479-91-4 | 分子量 | 374.341 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 617.7±55.0 °C at 760 mmHg | |
| 分子式 | C19H18O8 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 223.5±25.0 °C |
|
Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract.
Int. J. Oncol. 45(2) , 843-52, (2014) We have demonstrated that an extract from the ripe fruit of Vitex angus-castus (Vitex), might be a promising anticancer candidate. In order to further provide a molecular rationale for clinical development in anticancer therapy, a detailed mechanism underlyin... |
|
|
Opioidergic mechanisms underlying the actions of Vitex agnus-castus L.
Biochem. Pharmacol. 81(1) , 170-7, (2011) Vitex agnus-castus (VAC) has been used since ancient Greek times and has been shown clinically to be effective for the treatment of pre-menstrual syndrome. However, its mechanism of action has only been partially determined. Compounds, fractions, and extracts... |
|
|
G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.).
Cancer Lett. 208(1) , 59-64, (2004) Flavonoids are distributed in many plants. We studied the antitumor effects of flavonoids isolated from Viticis Fructus, casticin, artemetin, quercetagetin and 5,3'-dihydroxy-6,7,4' -trimethoxyflavanone. Casticin inhibited the growth of KB cells markedly (IC(... |
|
|
Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus.
Phytother Res. 23(11) , 1516-20, (2009) Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation and cytotoxicity. Castic... |
|
|
Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells.
Oncol. Rep. 29(2) , 474-80, (2013) We investigated the effect of casticin on apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). We found that casticin potentiated TRAIL-induced apoptosis in human colon cancer cells. Casticin downregulated cell survival ... |
|
|
Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro.
Acta Pharmacol. Sin. 31(12) , 1564-8, (2010) to investigate the anti-hyperprolactinemia activity of casticin, a flavonoid isolated from Vitex rotundifolia, and elucidate its molecular mechanism.hyperprolactinemia (MIHP) was induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, ... |
|
|
Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome.
J. Pharm. Pharmacol. 59(9) , 1307-12, (2007) The ethanol extract of the fruits of Vitex rotundifolia (VRE) and its four major compounds (casticin, luteolin, rotundifuran and agnuside) were tested for their estrogen-like activity by using the modified cell proliferation assay (E-SCREEN assessment system)... |
|
|
Quantitative determination and pharmacokinetic study of casticin in rat plasma by liquid chromatography-mass spectrometry.
J. Pharm. Biomed. Anal. 61 , 242-6, (2012) A specific and sensitive liquid chromatography-mass spectrometry method has been developed and validated for identification and quantification of casticin in rat plasma after oral and intravenous administrations. Kaempferol was employed as an internal standar... |
|
|
Metabolism studies of casticin in rats using HPLC-ESI-MS(n).
Biomed. Chromatogr. 26(12) , 1502-8, (2012) Casticin (3',5-dihydroxy-3, 4',6,7-tetramethoxyflavone) has been revealed to possess various kinds of pharmacological activities, including immunomodulatory, anti-hyperprolactinemia, anti-tumor and neuroprotetective activities. In order to gain an understandi... |
|
|
Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin.
Cancer Genomics Proteomics 9(3) , 143-51, (2012) Natural polyphenols play an important role in tumor inhibition. We used a doxorubicin-sensitive acute T-lymphoblastic leukemia cell line (CCRF-CEM) and its multidrug-resistant subline (CEM/ADR5000) to evaluate the activity of 15 plant polyphenols isolated in ... |