左羟丙哌嗪结构式
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常用名 | 左羟丙哌嗪 | 英文名 | Levodropropizine |
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| CAS号 | 99291-25-5 | 分子量 | 236.310 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 412.7±34.0 °C at 760 mmHg | |
| 分子式 | C13H20N2O2 | 熔点 | 102-106ºC | |
| MSDS | N/A | 闪点 | 220.9±24.3 °C |
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Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough.
J. Int. Med. Res. 23(3) , 175-83, (1995) The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for efficacy. Patients randomly received either 1 mg/kg dropropi... |
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Efficacy of levodropropizine in pediatric cough.
Pulm. Pharmacol. Ther. 25(5) , 337-42, (2012) Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respiratory tract infections. The morbidity associated with acute... |
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Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.
Ther. Drug Monit. 26(4) , 441-9, (2004) Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chromatography-mass spectrometry (GC-MS). The metabolism studies ... |
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Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea.
Eur. J. Pharmacol. 243(1) , 1-6, (1993) We investigated the effect of the non-opioid, peripherally acting antitussive agent levodropropizine to reduce neurogenic plasma extravasation in the rat trachea. Levodropropizine (10, 50 and 200 mg/kg) reduced in a dose-dependent manner the extravasation of ... |
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Levodropropizine does not affect P0.1 and breathing pattern in healthy volunteers and patients with chronic respiratory impairment.
Pulm. Pharmacol. Ther. 16(4) , 231-6, (2003) To evaluate whether the peripherally acting antitussive levodropropizine could affect the respiratory drive and the breathing pattern, we performed a double-blind, randomised, cross-over trial in 12 healthy volunteers and 12 patients with chronic respiratory ... |
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A case of immunoglobulin E mediated anaphylaxis to levodropropizine.
Yonsei Med. J. 54(1) , 262-4, (2013) We experienced a case of immunoglobulin E (IgE) mediated anaphylaxis to levodropropizine. The patient was an 18-year old Korean woman. After taking the common cold medication including acetaminophen, domperidone, and levodropropizine, skin rash, angioedema an... |
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HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.
Arch. Pharm. Res. 29(6) , 514-9, (2006) A simple HPLC method using UV detection was developed and validated for the determination of levodropropizine (LDP) in dog plasma. The sample was prepared for injection using a liquid-liquid extraction method with 1-phenypiperazine as the internal standard. T... |
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The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.
Bratisl. Lek. Listy 110(5) , 269-75, (2009) The ATP-sensitive potassium ion channels (K+ATP) are widely expressed on airway sensory nerves that mediate cough and other protective reflexes; dependent on airways smooth muscles (ASM) reactivity.The study was conducted to determine the involvement of K+ATP... |
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Relative bioavailability of levodropropizine 60 mg capsule and syrup formulations in healthy male Korean volunteers: a singledose, randomized-sequence, open-label, two-way crossover study.
Int. J. Clin. Pharmacol. Ther. 51(2) , 152-60, (2013) Levodropropizine is an oral non-opioid anti-tussive drug used in treatment of cough. A new generic 60 mg capsule formulation of levodropropizine has recently been developed.The aim of this study was to assess the pharmacokinetics and bioequivalence of the tes... |
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An anaphylactic reaction caused by levodropropizine.
Allergy 65(3) , 409-10, (2010)
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