利福布汀结构式
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常用名 | 利福布汀 | 英文名 | Rifabutin |
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| CAS号 | 72559-06-9 | 分子量 | 847.005 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 969.6±65.0 °C at 760 mmHg | |
| 分子式 | C46H62N4O11 | 熔点 | 169-171ºC | |
| MSDS | 中文版 美版 | 闪点 | 540.2±34.3 °C |
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Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.
J. Pharm. Biomed. Anal. 102 , 9-16, (2014) A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for therapeutic drug monitoring. Two protein precipitation methods w... |
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Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection.
World J. Gastroenterol. 20(43) , 16245-51, (2014) To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori (H. pylori) therapy-naive or pre-treated.H. pylori strains were isolated from antrum and corpus biopsies from 66 patien... |
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Genipin crosslinked ethyl cellulose-chitosan complex microspheres for anti-tuberculosis delivery.
Colloids Surf. B Biointerfaces 103 , 530-7, (2013) Genipin-crosslinked complex microspheres made of the combination of two polymers, ethyl cellulose and chitosan, were prepared by spray drying method. Rifabutin, an anti-tuberculosis agent was used as a model drug. Effects of various specifications of ethyl ce... |
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Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.
Antimicrob. Agents Chemother. 58(6) , 3168-76, (2014) Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS c... |
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Rifabutin reduces systemic exposure of an antimalarial drug 97/78 upon co-administration in rats: An in-vivo &in-vitro analysis.
Asian Pac. J. Trop. Med. 8 , 630-5, (2015) To determine the potential drug-drug interactions between anti-malarial candidate 97/78 and anti-tubercular drug rifabutin in-vivo in rats followed by in-vitro investigation of the underlying mechanisms of drug interaction.Single oral dose study was conducted... |
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Bacteriological characterization of a Mycobacterium parascrofulaceum strain isolated from a Chinese pneumonia patient.
Int. J. Infect. Dis. 25 , 82-7, (2014) A Mycobacterium parascrofulaceum strain was isolated from a pneumonia patient-the first such reported case from China. The bacteriological characteristics of the strain were determined.Species identification was performed by homologue gene sequence comparison... |
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Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Biol. Pharm. Bull. 38 , 1425-9, (2015) The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in vivo drug-drug interactions (DDIs) from in vitro data. Rifampicin, rifabutin, and thioacetazone inh... |
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Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs.
J. Infect. Dis. 210(3) , 456-66, (2014) Drug tolerance likely represents an important barrier to tuberculosis treatment shortening. We previously implicated the Mycobacterium tuberculosis efflux pump Rv1258c as mediating macrophage-induced tolerance to rifampicin and intracellular growth. In this s... |
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Rifamycin Derivatives Are Effective Against Staphylococcal Biofilms In Vitro and Elutable From PMMA.
Clin. Orthop. Relat. Res. 473 , 2874-84, (2015) Local antimicrobial delivery through polymethylmethacrylate beads (PMMA), commonly vancomycin, is used for the treatment of contaminated open fractures but has limited activity against Staphylococcus aureus biofilms, which occur commonly in such fractures. Ri... |
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Helicobacter pylori first-line and rescue treatments in the presence of penicillin allergy.
Dig. Dis. Sci. 60(2) , 458-64, (2015) Helicobacter pylori eradication is a challenge in penicillin allergy.To assess the efficacy and safety of first-line and rescue treatments in patients allergic to penicillin.Prospective multicenter study. Patients allergic to penicillin were given a first-lin... |