二苯并环庚酮
二苯并环庚酮结构式
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常用名 | 二苯并环庚酮 | 英文名 | Dibenzosuberone |
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| CAS号 | 1210-35-1 | 分子量 | 208.255 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 378.3±0.0 °C at 760 mmHg | |
| 分子式 | C15H12O | 熔点 | 32-34 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 158.3±20.1 °C |
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The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.
Pharmeur. Sci. Notes 2005(1) , 15-20, (2005) An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has been validated and is capable of controlling impurities to 0.... |
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Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.
J. Med. Chem. 56(1) , 241-53, (2013) p38α mitogen-activated protein (MAP) kinase is a main target in drug research concerning inflammatory diseases. Nevertheless, no inhibitor of p38α MAP kinase has been introduced to the market. This might be attributed to the fact that there is no inhibitor wh... |
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Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.
J. Med. Chem. 55(12) , 5868-77, (2012) Synthesis, biological testing, structure-activity relationships (SARs), and selectivity of novel disubstituted dibenzosuberone derivatives as p38 MAP kinase inhibitors are described. Hydrophilic moieties were introduced at the 7-, 8-, and 9-position of the 2-... |
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Simulation of the hepatic metabolism of stilbene and its tricyclic derivatives by Fenton and Ruff reagents: models for cytochrome P-450 activation of chemical carcinogens.
Biopharm. Drug Dispos. 11(1) , 39-51, (1990) Reactions of trans-stilbene, cis-stilbene, 5H-dibenzo [a,d] cyclo-heptene 5-one and 5H-dibenz [b,f] azepine (iminostilbene) with Fenton reagent [Fe (II)/H2O2] clearly simulate their hepatic metabolism. Expoxidation on the corresponding ethylenic linkage was f... |
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Synthesis of novel, potentially biologically active dibenzosuberone derivatives.
Molecules 10(12) , 1429-37, (2005) Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,1... |